3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Associations between diabetes mellitus and pulmonary hypertension in chronic respiratory disease patients

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Pulmonary hypertension (PH) is a common complication of chronic respiratory disease. Recent studies have reported diabetes mellitus (DM) to be a poor prognostic factor in patients with chronic respiratory disease, including chronic obstructive pulmonary disease or interstitial pneumoniae. However, the association between DM and PH in chronic respiratory disease remains unclear. In this study, we aimed to investigate whether DM is a predictor of PH in patients with chronic respiratory disease.

          Methods

          We prospectively analyzed 386 patients in our hospital with chronic respiratory disease. An echocardiographic pressure gradient between the right atrium and the right ventricle of 40 mmHg was defined as PH. We compared the clinical characteristics and impact of DM between chronic respiratory disease patients with and those without PH.

          Results

          Of the 386 patients, 42 (10.9%) were diagnosed as having PH. The PH group had higher modified medical research council (mMRC) grade and complication rate of DM, but not hypertension and hyperlipidemia, when compared to the non-PH group. Multivariable logistic regression analysis revealed that mMRC scale (odds ratio 1.702, 95% confidence interval, 1.297 to 2.232, P < 0.001) and presence of DM (odd ratio 2.935, 95% confidence interval, 1.505 to 5.725, P = 0.002) were associated with PH in chronic respiratory disease patients.

          Conclusion

          DM is potentially associated with PH and is an independent factor for prediction of PH in patients with chronic respiratory disease.

          Related collections

          Most cited references19

          • Record: found
          • Abstract: not found
          • Article: not found

          Executive summary of the Japan Atherosclerosis Society (JAS) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan -2012 version.

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Insulin resistance in pulmonary arterial hypertension.

            Although obesity, dyslipidemia and insulin resistance (IR) are well known risk factors for systemic cardiovascular disease, their impact on pulmonary arterial hypertension (PAH) is unknown. The present authors' previous studies indicate that IR may be a risk factor for PAH. The current study has investigated the prevalence of IR in PAH and explored its relationship with disease severity. Clinical data and fasting blood samples were evaluated in 81 nondiabetic PAH females. In total, 967 National Health and Nutrition Examination Surveys (NHANES) females served as controls. The fasting triglyceride to high-density lipoprotein cholesterol ratio was used as a surrogate of insulin sensitivity. While body mass index was similar in NHANES versus PAH females (28.6 versus 28.7 kg.m(-2)), PAH females were more likely to have IR (45.7 versus 21.5%) and less likely to be insulin sensitive (IS; 43.2 versus 57.8%). PAH females mostly (82.7%) had New York Heart Association (NYHA) class II and III symptoms. Aetiology, NYHA class, 6-min walk-distance and haemodynamics did not differ between IR and IS PAH groups. However, the presence of IR and a higher NYHA class was associated with poorer 6-months event-free survival (58 versus 79%). Insulin resistance appears to be more common in pulmonary arterial hypertension females than in the general population, and may be a novel risk factor or disease modifier that might impact on survival.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              How does comorbidity influence survival in idiopathic pulmonary fibrosis?

              Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. It is a serious and progressive lung disease with a median survival of three years. The role of comorbidities in the prognosis of IPF is not clear.
                Bookmark

                Author and article information

                Contributors
                Role: Data curationRole: Investigation
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: MethodologyRole: Writing – review & editing
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole: Writing – original draft
                Role: Writing – review & editing
                Role: Writing – review & editing
                Role: Writing – review & editing
                Role: Writing – review & editing
                Role: Writing – review & editing
                Role: SupervisionRole: Validation
                Role: Supervision
                Role: Project administrationRole: SupervisionRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                9 October 2018
                2018
                : 13
                : 10
                : e0205008
                Affiliations
                [1 ] Clinical Research Center, Fukushima Medical University Hospital, Fukushima, Japan
                [2 ] Department of Advanced Cardiac Therapeutics, Fukushima Medical University, Fukushima, Japan
                [3 ] Department of Pulmonary Hypertension, Fukushima Medical University, Fukushima, Japan
                [4 ] Department of Arrhythmia and Cardiac Pacing, Fukushima Medical University, Fukushima, Japan
                [5 ] Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan
                Kurume University School of Medicine, JAPAN
                Author notes

                Competing Interests: We have the following interests: Koichi Sugimoto and Tetsuro Yokokawa belong to endowed department sponsored by Acterion Pharmaceuticals Japan. Akiomi Yoshihisa and Tomofumi Misaka belong to endowed department sponsored by Fukuda denshi. Takashi Kaneshiro belongs to endowed department sponsored by Biotronic Japan and Abbott Japan. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials. All other authors declare that no competing interest exists.

                Author information
                http://orcid.org/0000-0002-7527-7288
                Article
                PONE-D-18-14915
                10.1371/journal.pone.0205008
                6177140
                30300400
                e7f70e32-061a-4073-a228-a84f263c84b0
                © 2018 Takahashi et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 18 May 2018
                : 18 September 2018
                Page count
                Figures: 1, Tables: 4, Pages: 10
                Funding
                Acterion Pharmaceuticals Japan provided support in the form of salaries for authors [K.S., T.Y.], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Fukuda denshi provided support in the form of salaries for authors [A.Y., T.M.], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Biotronic Japan and Abbot Japan provided support in the form of salaries for authors [T.K.], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Medicine and Health Sciences
                Endocrinology
                Endocrine Disorders
                Diabetes Mellitus
                Medicine and Health Sciences
                Metabolic Disorders
                Diabetes Mellitus
                Medicine and Health Sciences
                Pulmonology
                Chronic Obstructive Pulmonary Disease
                Medicine and Health Sciences
                Pulmonology
                Medicine and Health Sciences
                Vascular Medicine
                Blood Pressure
                Medicine and Health Sciences
                Diagnostic Medicine
                Diagnostic Radiology
                Ultrasound Imaging
                Echocardiography
                Research and Analysis Methods
                Imaging Techniques
                Diagnostic Radiology
                Ultrasound Imaging
                Echocardiography
                Medicine and Health Sciences
                Radiology and Imaging
                Diagnostic Radiology
                Ultrasound Imaging
                Echocardiography
                Medicine and Health Sciences
                Pulmonology
                Pulmonary Hypertension
                Biology and Life Sciences
                Anatomy
                Cardiovascular Anatomy
                Blood Vessels
                Arteries
                Pulmonary Arteries
                Medicine and Health Sciences
                Anatomy
                Cardiovascular Anatomy
                Blood Vessels
                Arteries
                Pulmonary Arteries
                Medicine and Health Sciences
                Metabolic Disorders
                Dyslipidemia
                Custom metadata
                All relevant data are within the paper.

                Uncategorized
                Uncategorized

                Comments

                Comment on this article