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      Lipoprotein Lipid Abnormalities in Healthy Renal Transplant Recipients: Persistence of Low HDL 2 Cholesterol

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          Abstract

          There is disagreement about the prevalence and character of lipoprotein lipid abnormalities in renal transplant patients. To test the hypothesis that these abnormalities may be related to the coexistence of medical conditions and medications which affect lipoprotein metabolism in these patients, triglyceride (TG), cholesterol (C), high-density lipoprotein (HDL) and HDL-C subfractions were measured in 26 transplanted patients (10 F/16 M), control subjects matched for age, sex, weight and race and uremic patients being treated with hemodialysis. Female transplant recipients had higher TG (181 ± 47 vs. 68 ± 6 mg/dl; p < 0.001), C (242 ± 19 vs. 165 ± 9 mg/dl; p < 0.01), and low-density lipoprotein (LDL)-C (155 ± 15 vs. 93 ± 8 mg/dl; p < 0.01) than controls. Levels of HDL-C were similar, but HDL<sub>2</sub> was significantly lower in the transplanted patients (9 ± 2 vs. 19 ± 2 mg/dl; p < 0.01). Compared to the uremic patients, female transplanted patients had higher C (242 ± 19 vs. 178 ± 22 mg/dl; p < 0.01), LDL-C (155 ± 15 vs. 94 ± 18 mg/dl; p < 0.01), HDL-C (51 ± 5 vs. 32 ± 4 mg/dl; p < 0.001) and HDL<sub>3</sub>-C (42 ± 4 vs. 26 ± 2 mg/dl; p < 0.001); however, HDL<sub>2</sub>-C levels were not significantly different. Similarly, male transplanted patients had higher TG (166 ± 26 vs. 100 + 12 mg/dl; p < 0.01), C (213 ± 10 vs. 158 ± 3 mg/dl; p < 0.01), LDL-C (126 ± 9 vs. 97 ± 3 mg/dl; p < 0.05) and HDL-C (54 ± 4 vs. 41 ± 3 mg/dl; p < 0.05) than controls and higher HDL (54 ± 4 vs. 36 ± 4 mg/dl; p < 0.05) and HDL<sub>3 </sub>(47 ± 3 vs. 30 ± 2 mg/dl; p < 0.05) than uremic patients. However, HDL<sub>2</sub>-C levels did not differ among the transplanted, control or uremic groups. Thus, both male and female renal transplant recipients who are otherwise healthy have elevated plasma TG, C and LDL-C and normal to high levels of HDL-C; however their HDL<sub>2</sub>-C levels are low. These abnormalities may explain why renal transplant recipients have an increased incidence of atherosclerotic vascular disease.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1987
          1987
          05 December 2008
          : 47
          : 1
          : 17-21
          Affiliations
          Department of Medicine, The Johns Hopkins School of Medicine and the Gerontology Research Center, National Institute on Aging, Baltimore, Md., USA
          Article
          184450 Nephron 1987;47:17–21
          10.1159/000184450
          3306427
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

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