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      Comparative studies of gene expression and the evolution of gene regulation.

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          Abstract

          The hypothesis that differences in gene regulation have an important role in speciation and adaptation is more than 40 years old. With the advent of new sequencing technologies, we are able to characterize and study gene expression levels and associated regulatory mechanisms in a large number of individuals and species at an unprecedented resolution and scale. We have thus gained new insights into the evolutionary pressures that shape gene expression levels and have developed an appreciation for the relative importance of evolutionary changes in different regulatory genetic and epigenetic mechanisms. The current challenge is to link gene regulatory changes to adaptive evolution of complex phenotypes. Here we mainly focus on comparative studies in primates and how they are complemented by studies in model organisms.

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          Author and article information

          Journal
          Nat Rev Genet
          Nature reviews. Genetics
          Springer Science and Business Media LLC
          1471-0064
          1471-0056
          Jun 18 2012
          : 13
          : 7
          Affiliations
          [1 ] Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.
          Article
          nrg3229 NIHMS575834
          10.1038/nrg3229
          4034676
          22705669
          e8001a2d-403d-45fc-9858-02895d416792
          History

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