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      Regulators of PP2C phosphatase activity function as abscisic acid sensors.

      Science (New York, N.Y.)

      Up-Regulation, Abscisic Acid, Stereoisomerism, Signal Transduction, metabolism, Recombinant Fusion Proteins, Point Mutation, Plants, Genetically Modified, physiology, Plant Stomata, growth & development, Plant Roots, genetics, chemistry, antagonists & inhibitors, Phosphoprotein Phosphatases, Molecular Sequence Data, Germination, Gene Expression Regulation, Plant, Carrier Proteins, Binding Sites, Arabidopsis Proteins, Arabidopsis, Amino Acid Sequence, pharmacology

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          Abstract

          The plant hormone abscisic acid (ABA) acts as a developmental signal and as an integrator of environmental cues such as drought and cold. Key players in ABA signal transduction include the type 2C protein phosphatases (PP2Cs) ABI1 and ABI2, which act by negatively regulating ABA responses. In this study, we identify interactors of ABI1 and ABI2 which we have named regulatory components of ABA receptor (RCARs). In Arabidopsis, RCARs belong to a family with 14 members that share structural similarity with class 10 pathogen-related proteins. RCAR1 was shown to bind ABA, to mediate ABA-dependent inactivation of ABI1 or ABI2 in vitro, and to antagonize PP2C action in planta. Other RCARs also mediated ABA-dependent regulation of ABI1 and ABI2, consistent with a combinatorial assembly of receptor complexes.

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          Journal
          10.1126/science.1172408
          19407143

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