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      Regulators of PP2C phosphatase activity function as abscisic acid sensors.

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          Abstract

          The plant hormone abscisic acid (ABA) acts as a developmental signal and as an integrator of environmental cues such as drought and cold. Key players in ABA signal transduction include the type 2C protein phosphatases (PP2Cs) ABI1 and ABI2, which act by negatively regulating ABA responses. In this study, we identify interactors of ABI1 and ABI2 which we have named regulatory components of ABA receptor (RCARs). In Arabidopsis, RCARs belong to a family with 14 members that share structural similarity with class 10 pathogen-related proteins. RCAR1 was shown to bind ABA, to mediate ABA-dependent inactivation of ABI1 or ABI2 in vitro, and to antagonize PP2C action in planta. Other RCARs also mediated ABA-dependent regulation of ABI1 and ABI2, consistent with a combinatorial assembly of receptor complexes.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          1095-9203
          0036-8075
          May 22 2009
          : 324
          : 5930
          Affiliations
          [1 ] Lehrstuhl für Botanik, Technische Universität München, Am Hochanger 4, D-85354 Freising, Germany.
          Article
          1172408
          10.1126/science.1172408
          19407143
          e8011e50-c311-4f17-96c6-f7b64ee8a625
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