Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Evaluation of Antianginal Drug Treatment by Precordial Exercise Electrocardiography

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          We tried to assess the efficacy of precordial exercise electrocardiography (PEE) in evaluating various antianginal drugs. PEE was performed by 18 precordial electrodes. Leads V2-V7 were recorded at their usual position and one intercostal space higher and lower. The Bruce treadmill exercise protocol was used. A positivity index (PI) was formulated as follows. The total sum of maximal ST-segment depression (ΣST⇓) × 100 was divided by the product of the number of precordial leads × minutes of exercise duration: PI=ΣST⇓ × 100/n precordial leads × min The PI was measured basally and after the administration of nitroglycerin (NTG) ointment, 7.5 mg (7 patients), propranolol (P) 20–40 mg, 3 times daily (7 patients) and nifedipine (N), 10 mg 3–4 times daily (7 patients). A significant decrease of the PI was seen with NTG (p < 0.01) and P (p < 0.05) but not with N. However, in the N group, 2 patients had a significant increase in heart frequency, with resultant exercise deterioration. The remaining 6 patients had a satisfactory response to the drug (p < 0.05). The PI is useful in assessing the antianginal efficacy of various medications. From our study it is suggested that inordinate tachycardia may negate the beneficial effect of N in some patients.

          Related collections

          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          978-3-8055-3437-6
          978-3-318-00026-9
          0008-6312
          1421-9751
          1981
          1981
          07 November 2008
          : 68
          : Suppl 2
          : 141-146
          Affiliations
          Department of Cardiology, Tzanio State Hospital, Pireus, Greece
          Article
          173329 Cardiology 1981;68:141–146
          10.1159/000173329
          6797732
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Drug Effect

          Comments

          Comment on this article