Differential Contractile Responses of Pressurized Porcine Coronary Resistance-Sized and Conductance Coronary Arteries to Acetylcholine, Histamine and Prostaglandin F 2α

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Abstract

The reactivities of porcine resistance-sized arteries (270 µm o.d.) and conductance coronary arteries (4.2 mm o.d.) were compared in the presence of a functional and morphologically intact endothelium using a pressurized in vitro preparation. In resistance vessels, acetylcholine (ACh) produced maximal diameter reductions of 42 % and the EC50 was 0.19 µM. Constrictions to histamine and prostaglandin F2α (PGF2«), however, were either absent or minimal. In contrast, maximum diameter constrictions of conductance vessels were 19, 33 and 22% in response to ACh, histamine and PGF2α, respectively. Corresponding EC50 values were 0.58, 2.8 and 2.9 µM. The significant differences in reactivity between resistance and conductance arteries underscore the potential importance of regional specialization in the coronary blood flow regulation.

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Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1989

Publication date (Print): 1989

Publication date (Electronic): 23 September 2008

Volume: 26

Issue: 4

Pages: 235-245

Affiliations

^aDepartment of Surgery, Shimane Medical University, Izumo, Japan, and ^bDepartments of Physiology and Biophysics, and Obstetrics and Gynecology, University of Vermont, College of Medicine, Burlington, Vt., USA

Article

Publisher ID: 158771 Other ID: Blood Vessels 1989;26:235–245

DOI: 10.1159/000158771

SO-VID: e8477aa1-12d6-43df-917c-6c104f8836d8

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 16 December 1988

Date accepted : 14 July 1989

Page count

Pages: 11

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Differential Contractile Responses of Pressurized Porcine Coronary Resistance-Sized and Conductance Coronary Arteries to Acetylcholine, Histamine and Prostaglandin F _2α

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