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      Hypocalcemia and Myocardial Function in Uremia

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          Abstract

          To investigate whether hypocalcemia affects cardiac performance in uremic patients, we studied the hemodynamic changes with short- and long-term correction of hypocalcemia in 4 uremic patients on dialysis using continuous wave Doppler study. At rest, 1 h of intravenous calcium infusion increased calcium level from 1.74 ± 0.17 to 1.92 ± 0.16 mmol/l (p < 0.05). Cardiac output represented by minute distance increased from 10.5 ± 2.0 to 12.1 ± 2.5 m (p < 0.05), but heart rate and blood pressure were unchanged. The peak velocity and acceleration of ascending aortic blood flow increased during calcium infusion. With long-term replacement, calcium level increased from 1.74 ± 0.17 to 1.94 ± 0.15 mmol/l (p < 0.05), but resting hemodynamics were unchanged. On exercise testing, exercise duration increased from 10.6 ± 1.6 min to 12.9 ± 1.5 min (p < 0.01), but hemodynamic parameters at peak exercise were similar. We conclude that acute calcium replacement enhanced cardiac contractility in uremic patients, but cardiac performance at rest and peak hxercise was not improved with long-term therapy. This reflects different cardiac responses to acute versus chronic calcium replacement.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1992
          1992
          12 November 2008
          : 80
          : 1
          : 7-11
          Affiliations
          Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
          Article
          174973 Cardiology 1992;80:7–11
          10.1159/000174973
          1555217
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          General Cardiology

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