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      Microbioreactor Systems for Accelerated Bioprocess Development.

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          Abstract

          In recent years, microbioreactor (MBR) systems have evolved towards versatile bioprocess engineering tools. They provide a unique solution to combine higher experimental throughput with extensive bioprocess monitoring and control, which is indispensable to develop economically and ecologically competitive bioproduction processes. MBR systems are based either on down-scaled stirred tank reactors or on advanced shaken microtiter plate cultivation devices. Importantly, MBR systems make use of optical measurements for non-invasive, online monitoring of important process variables like biomass concentration, dissolved oxygen, pH, and fluorescence. The application range of MBR systems can be further increased by integration into liquid handling robots, enabling automatization and, thus standardization, of various handling and operation procedures. Finally, the tight integration of quantitative strain phenotyping with bioprocess development under industrially relevant conditions greatly increases the probability of finding the right combination of producer strain and bioprocess control strategy. This review will discuss the current state of the art in the field of MBR systems and we can readily conclude that their importance for industrial biotechnology will further increase in the near future.

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          Author and article information

          Journal
          Biotechnol J
          Biotechnology journal
          Wiley
          1860-7314
          1860-6768
          Apr 2018
          : 13
          : 4
          Affiliations
          [1 ] Forschungszentrum Jülich, Institute of Bio- and Geosciences - Biotechnology (IBG-1), Wilhelm-Johnen Straße 1, 52425, Jülich, Germany.
          [2 ] Bioeconomy Science Center (BioSC), c/o Forschungszentrum Jülich, 52425 Jülich, Germany.
          [3 ] RWTH Aachen University, Computational Systems Biotechnology (AVT.CSB), Forckenbeckstraße 51, 52074 Aachen, Germany.
          [4 ] RWTH Aachen University, Institute of Biotechnology, Worringer Weg 3, 52074 Aachen, Germany.
          Article
          10.1002/biot.201700141
          29283217
          e85e8e06-6f3f-4c86-9106-32e6a81486f5
          History

          lab automation,micro-scale cultivation,industrial biotechnology and bioeconomy,accelerated bioprocess development,quantitative microbial phenotyping

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