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      HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis.

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          Abstract

          In the Step Study, the MRKAd5 HIV-1 gag/pol/nef vaccine did not reduce plasma viraemia after infection, and HIV-1 incidence was higher in vaccine-treated than in placebo-treated men with pre-existing adenovirus serotype 5 (Ad5) immunity. We assessed vaccine-induced immunity and its potential contributions to infection risk.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          1474-547X
          0140-6736
          Nov 29 2008
          : 372
          : 9653
          Affiliations
          [1 ] Vaccine and Infectious Disease Institute and the HIV Vaccine Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Medicine, The University of Washington, Seattle, WA, USA; Department of Laboratory Medicine, The University of Washington, Seattle, WA, USA. Electronic address: jmcelrat@fhcrc.org.
          [2 ] Vaccine and Infectious Disease Institute and the HIV Vaccine Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Laboratory Medicine, The University of Washington, Seattle, WA, USA.
          [3 ] Vaccine and Infectious Disease Institute and the HIV Vaccine Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
          [4 ] Merck Research Laboratories, West Point, PA, USA.
          [5 ] Emory Vaccine Center, Emory University, Atlanta, GA, USA.
          [6 ] HIV Research Section, San Francisco Department of Public Health, San Francisco, CA, USA.
          [7 ] Vaccine and Infectious Disease Institute and the HIV Vaccine Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Biostatistics, The University of Washington, Seattle, WA, USA.
          [8 ] Vaccine and Infectious Disease Institute and the HIV Vaccine Trials Network, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Medicine, The University of Washington, Seattle, WA, USA; Department of Laboratory Medicine, The University of Washington, Seattle, WA, USA.
          Article
          S0140-6736(08)61592-5 NIHMS109576
          10.1016/S0140-6736(08)61592-5
          2774110
          19012957
          e883633a-65b8-46db-9d01-2a88c2bf3c6e
          History

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