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      Antibiotic development — economic, regulatory and societal challenges

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          Drugs for bad bugs: confronting the challenges of antibacterial discovery.

          The sequencing of the first complete bacterial genome in 1995 heralded a new era of hope for antibacterial drug discoverers, who now had the tools to search entire genomes for new antibacterial targets. Several companies, including GlaxoSmithKline, moved back into the antibacterials area and embraced a genomics-derived, target-based approach to screen for new classes of drugs with novel modes of action. Here, we share our experience of evaluating more than 300 genes and 70 high-throughput screening campaigns over a period of 7 years, and look at what we learned and how that has influenced GlaxoSmithKline's antibacterials strategy going forward.
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            Consumption of oral antibiotic formulations for young children according to the WHO Access, Watch, Reserve (AWaRe) antibiotic groups: an analysis of sales data from 70 middle-income and high-income countries

            The 2017 WHO Model List of Essential Medicines for Children (EMLc) groups antibiotics as Access, Watch, or Reserve, based on recommendations of their use as first-choice and second-choice empirical treatment for the most common infections. This grouping provides an opportunity to review country-level antibiotic consumption and a potential for stewardship. Therefore, we aimed to review 2015 levels of oral antibiotic consumption by young children globally.
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              Non-traditional Antibacterial Therapeutic Options and Challenges

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                Author and article information

                Journal
                Nature Reviews Microbiology
                Nat Rev Microbiol
                Springer Science and Business Media LLC
                1740-1526
                1740-1534
                November 19 2019
                Article
                10.1038/s41579-019-0293-3
                31745330
                e89c4b96-8002-40bd-8d5b-545e97607d75
                © 2019

                http://www.springer.com/tdm

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