Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

Changes in plasma IL4, TNFá and CRP in response to regular passive smoking at home among healthy school children in Khartoum, Sudan.

African health sciences

blood, Tumor Necrosis Factor-alpha, adverse effects, Tobacco Smoke Pollution, Smoking, Schools, Questionnaires, Parents, Male, Interleukin-4, Humans, Female, Enzyme-Linked Immunosorbent Assay, Child, Case-Control Studies, analysis, C-Reactive Protein, Biological Markers, Adolescent

Read this article at

ScienceOpenPMC
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Regular exposure to tobacco smoke at home causes airway inflammation and altered cytokine regulation; however, there is variation between individuals of different countries. To determine effects of passive smoking on plasma IL4, TNFá, and CRP in healthy male school-children in Khartoum. A total of 135 male school-pupils (69 passive smokers and 66 non-smokers) were selected randomly from three primary schools for boys in Khartoum. Information about smoking history was collected from each pupil and his parents using a questionnaire. Plasma CRP, IL4 and TNFá were measured using commercially available ELISA kits. Plasma IL4 and TNFá in the passive smokers (mean ± SEM) is at 2.92 ± 0.93 and 19.78 ± 4.67 pg/ml respectively; whereas in the non-smokers . It is at 0.45 ± 0.28 and 5.05 ± 1.54 pg/ml respectively. The difference between the two groups is statistically significant (p <0.05). The mean plasma IL4 and TNFá were lowest with no exposure, higher with moderate exposure, and highest with heavy exposure (P < 0.05). Plasma CRP showed insignificant difference between the two groups. Passive smoking causes significant rise in plasma TNFá and IL4 with a dose dependent effect among school-pupils in Khartoum.

      Related collections

      Author and article information

      Journal
      3462520
      23066418

      Comments

      Comment on this article