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      Association of Soluble Suppression of Tumorigenicity 2 with New-Onset Atrial Fibrillation in Acute Myocardial Infarction

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          Abstract

          Background: The combination of acute myocardial infarction (AMI) and atrial fibrillation (AF) is still a thorny problem in the clinic. At present, there are few reports on the role of soluble suppression of tumorigenicity 2 (sST2) in AF after AMI. This study was to explore the predictive value of sST2 in patients with AMI for new-onset AF. Methods: This is a single-center retrospective clinical observation study. We continuously included AMI patients from September 2019 to November 2021. The concentration of sST2 in blood samples was determined. During admission, a suspicious heart rhythm was recorded by electrocardiogram (ECG) monitoring, and new-onset AF was confirmed by immediate body surface ECG. Results: After multiple factors were included, age, right coronary artery, high-sensitivity C-reactive protein, left ventricular ejection fraction, and sST2 were still risk factors for new-onset AF. The area under curve value of age and sST2 was more than 0.7, which showed good diagnostic value. For reevaluation, the sST2 was added to the clinical new-onset AF prediction model. It was found that the integrated discrimination improvement and net reclassification index in the model were improved significantly. Conclusion: sST2 is an independent predictor of new-onset AF in patients with AMI and can improve the accuracy of the AF risk model.

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          Most cited references41

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          2013 ACCF/AHA guideline for the management of heart failure: a report of the American college of cardiology foundation/American heart association task force on practice guidelines

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            Worldwide epidemiology of atrial fibrillation: a global burden of disease 2010 study

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              2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)

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                Author and article information

                Journal
                CRD
                Cardiology
                10.1159/issn.0008-6312
                Cardiology
                S. Karger AG
                0008-6312
                1421-9751
                2022
                October 2022
                17 May 2022
                : 147
                : 4
                : 381-388
                Affiliations
                Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
                Article
                524765 Cardiology 2022;147:381–388
                10.1159/000524765
                35580569
                e8af25b6-0334-4035-a653-828aad3be32a
                © 2022 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

                History
                : 18 January 2022
                : 20 April 2022
                Page count
                Figures: 2, Tables: 4, Pages: 8
                Funding
                The authors did not receive any funding.
                Categories
                Cardiovascular Biomarkers: Research Article

                General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
                Soluble suppression of tumorigenicity 2,Cardiac biomarkers,Acute myocardial infarction,Atrial fibrillation

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