For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
46
references
 Top references
cited by
7
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      107
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Altered spontaneous brain activity patterns in patients with neovascular glaucoma using amplitude of low‐frequency fluctuations: A functional magnetic resonance imaging study

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Neovascular glaucoma (NVG) can cause irreversible visual impairment and abnormal spontaneous changes in brain's visual system and other systems. There is little research on this aspect at present. However, amplitude of low‐frequency fluctuations (ALFFs) can be used as an rs‐fMRI analysis technique for testing changes in spontaneous brain activity patterns.

          Purpose

          The aim of this study was to probe the local characteristics of spontaneous brain activity in NVG patients and analyze their correlation with clinical behaviors.

          Methods

          Resting‐state functional magnetic resonance imaging (rs‐fMRI) scans were obtained from eighteen patients with NVG (8 males, 10 females) and eighteen healthy controls (HCs; 8 males and 10 females) who were matched in age, gender, and education level. We evaluated spontaneous brain activity with the ALFF method. A receiver operating characteristic (ROC) curve was used to compare the average ALFF values for altered brain regions of NVG patients with those of HCs.

          Results

          Compared with HCs, NVG patients had lower ALFF values in the right cuneus, right middle occipital gyrus, left cingulate gyrus, right precuneus, and left medial frontal gyrus ( p < 0.001). Higher ALFF values were observed in the right superior frontal gyrus and left middle frontal gyrus ( p < 0.001). Analysis of the ROC curves of the brain regions showed that the specificity and accuracy of ALFF values between NVG and HCs in the area under the curve were acceptable ( p < 0.001).

          Conclusion

          The patients with NVG exhibited anomalous spontaneous activity in different brain regions; these finding should establish the foundation for a more comprehensive understanding of the pathological mechanisms of NVG. Furthermore, these abnormal variations in specific brain regions can be considered possible clinical indices of NVG.

          Abstract

          The patients with NVG exhibited anomalous spontaneous activity in different brain regions; these abnormal variations in specific brain regions can be considered possible clinical indices of NVG.

          Related collections

          Most cited references46

          • Record: found
          • Abstract: found
          • Article: not found

          Neurophysiological investigation of the basis of the fMRI signal.

          N. K. Logothetis, J Pauls, M Augath … (2001)
          Functional magnetic resonance imaging (fMRI) is widely used to study the operational organization of the human brain, but the exact relationship between the measured fMRI signal and the underlying neural activity is unclear. Here we present simultaneous intracortical recordings of neural signals and fMRI responses. We compared local field potentials (LFPs), single- and multi-unit spiking activity with highly spatio-temporally resolved blood-oxygen-level-dependent (BOLD) fMRI responses from the visual cortex of monkeys. The largest magnitude changes were observed in LFPs, which at recording sites characterized by transient responses were the only signal that significantly correlated with the haemodynamic response. Linear systems analysis on a trial-by-trial basis showed that the impulse response of the neurovascular system is both animal- and site-specific, and that LFPs yield a better estimate of BOLD responses than the multi-unit responses. These findings suggest that the BOLD contrast mechanism reflects the input and intracortical processing of a given area rather than its spiking output.
          Article 0 comments Cited 471 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The oscillating brain: complex and reliable.

            Xi-Nian Zuo, Adriana Di Martino, Clare Kelly … (2010)
            The human brain is a complex dynamic system capable of generating a multitude of oscillatory waves in support of brain function. Using fMRI, we examined the amplitude of spontaneous low-frequency oscillations (LFO) observed in the human resting brain and the test-retest reliability of relevant amplitude measures. We confirmed prior reports that gray matter exhibits higher LFO amplitude than white matter. Within gray matter, the largest amplitudes appeared along mid-brain structures associated with the "default-mode" network. Additionally, we found that high-amplitude LFO activity in specific brain regions was reliable across time. Furthermore, parcellation-based results revealed significant and highly reliable ranking orders of LFO amplitudes among anatomical parcellation units. Detailed examination of individual low frequency bands showed distinct spatial profiles. Intriguingly, LFO amplitudes in the slow-4 (0.027-0.073 Hz) band, as defined by Buzsáki et al., were most robust in the basal ganglia, as has been found in spontaneous electrophysiological recordings in the awake rat. These results suggest that amplitude measures of LFO can contribute to further between-group characterization of existing and future "resting-state" fMRI datasets.
            Article 0 comments Cited 244 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              When the brain loses its self: prefrontal inactivation during sensorimotor processing.

              Ilan Goldberg, Michal Harel, Rafael Malach (2006)
              A common theme in theories of subjective awareness poses a self-related "observer" function, or a homunculus, as a critical element without which awareness can not emerge. Here, we examined this question using fMRI. In our study, we compared brain activity patterns produced by a demanding sensory categorization paradigm to those engaged during self-reflective introspection, using similar sensory stimuli. Our results show a complete segregation between the two patterns of activity. Furthermore, regions that showed enhanced activity during introspection underwent a robust inhibition during the demanding perceptual task. The results support the notion that self-related processes are not necessarily engaged during sensory perception and can be actually suppressed.
              Article 0 comments Cited 168 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Yi Shao:
                ORCID: https://orcid.org/0000-0003-1571-2433
                freebee99@163.com
                Journal
                Journal ID (nlm-ta): Brain Behav
                Journal ID (iso-abbrev): Brain Behav
                Journal ID (doi): 10.1002/(ISSN)2157-9032
                Journal ID (publisher-id): BRB3
                Title: Brain and Behavior
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Electronic): 2162-3279
                Publication date (Electronic): 01 January 2021
                Publication date Collection: March 2021
                Volume: 11
                Issue: 3 ( doiID: 10.1002/brb3.v11.3 )
                Electronic Location Identifier: e02018
                Affiliations
                [ 1 ] Department of Ophthalmology The First Affiliated Hospital of Nanchang University Jiangxi Province Clinical Ophthalmology Institute Nanchang China
                Author notes
                [*] [* ] Correspondence

                Yi Shao, Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, 17 Yongwaizheng Street, Donghu, Nanchang, Jiangxi 330006, China.

                Email: freebee99@ 123456163.com

                Author information
                https://orcid.org/0000-0003-1571-2433
                Article
                Publisher ID: BRB32018
                DOI: 10.1002/brb3.2018
                PMC ID: 7994689
                PubMed ID: 33386699
                SO-VID: e8ba10a2-f15b-4312-956e-8867c2b71eb2
                Copyright © © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date revision received : 14 November 2020
                Date received : 29 May 2020
                Date accepted : 11 December 2020
                Page count
                Figures: 5, Tables: 4, Pages: 10, Words: 6388
                Funding
                Funded by: National Natural Science Foundation of China , open-funder-registry 10.13039/501100001809;
                Award ID: 81660158
                Award ID: 81460092
                Award ID: 81400372
                Funded by: Natural Science Key Project of Jiangxi Province
                Award ID: 20161ACB21017
                Categories
                Subject: Original Research
                Subject: Original Research
                Custom metadata
                source-schema-version-number 2.0
                cover-date March 2021
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.9 mode:remove_FC converted:26.03.2021

                ScienceOpen disciplines: Neurosciences
                Keywords: amplitude of low‐frequency fluctuations (alffs),brain activity patterns,correlation,neovascular glaucoma (nvg),rs‐fmri
                Data availability:
                ScienceOpen disciplines: Neurosciences
                Keywords: amplitude of low‐frequency fluctuations (alffs), brain activity patterns, correlation, neovascular glaucoma (nvg), rs‐fmri

                Comments

                Comment on this article

                scite_

                Similar content107

                See all similar

                Cited by7

                See all cited by

                Most referenced authors491

                See all reference authors