Anti-MOG (Myelin Oligodendrocyte Glycoprotein)–Positive Severe Optic Neuritis with Optic Disc Ischaemia and Macular Star

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Abstract

A 44-year-old man presented with severe right visual loss. The right fundus examination showed marked optic disc oedema associated with partial macular star. Serological blood tests for infectious agents were all negative. Serum aquaporin-4 antibody was negative but anti-MOG (myelin oligodendrocyte glycoprotein) was positive. Magnetic resonance revealed extensive lesion in right optic nerve. There was no visual improvement after intravenous therapy. Patient had no further attacks after follow-up. Optic disc oedema with macular star is found in several infectious and non-inflammatory disorders, but it has not been reported in optic neuritis (ON) associated with autoantibodies to myelin oligodendrocyte glycoprotein (anti-MOG).

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Author and article information

Journal

Journal ID (nlm-ta): Neuroophthalmology

Journal ID (iso-abbrev): Neuroophthalmology

Journal ID (publisher-id): IOPH

Journal ID (publisher-id): ioph20

Title: Neuro-Ophthalmology

Publisher: Informa Healthcare

ISSN (Print): 0165-8107

ISSN (Electronic): 1744-506X

Publication date Collection: December 2015

Publication date (Electronic): 10 November 2015

Volume: 39

Issue: 6

Pages: 285-288

Affiliations

[1 ] Department of Ophthalmology, Faculty of Medicine, University of Sao Paulo , Sao Paulo, Brazil,

[2 ] Department of Neurology, Faculty of Medicine, University of Sao Paulo , Sao Paulo, Brazil,

[3 ] Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine , Sendai, Japan, and

[4 ] Department of Radiology and Oncology, Faculty of Medicine, University of Sao Paulo , Sao Paulo, Brazil

Author notes

Correspondence: Dr. Frederico Castelo Moura, Department of Ophthalmology, Faculty of Medicine, University of Sao Paulo , Rua Mato Grosso, 306–414 Sao Paulo, SP, 01239-040, Brazil. E-mail: fredcastelo@ 123456usp.br

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/ioph

Article

Accession ID: PMC5122939 Pmcid ID: PMC5122939 Pmc-uid ID: 5122939 Publisher ID: 1084332

DOI: 10.3109/01658107.2015.1084332

PMC ID: 5122939

PubMed ID: 27928371

SO-VID: e8c0ee56-de29-408c-89f2-58b8b23bca27

History

Date received : 29 July 2015

Date accepted : 14 August 2015

Page count

Pages: 4

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