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Resistance diagnosis and the changing epidemiology of antibiotic resistance.

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      Abstract

      Widespread adoption of point-of-care resistance diagnostics (POCRD) reduces ineffective antibiotic use but could increase overall antibiotic use. Indeed, in the context of a standard susceptible-infected epidemiological model with a single antibiotic, POCRD accelerates the rise of resistance in the disease-causing bacterial population. When multiple antibiotics are available, however, POCRD may slow the rise of resistance even as more patients receive antibiotic treatment, belying the conventional wisdom that antibiotics are "exhaustible resources" whose increased use necessarily promotes the rise of resistance.

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      Author and article information

      Affiliations
      [1 ] Fuqua School of Business and Economics Department, Duke University, Durham, North Carolina.
      Journal
      Ann. N. Y. Acad. Sci.
      Annals of the New York Academy of Sciences
      Wiley
      1749-6632
      0077-8923
      January 2017
      : 1388
      : 1
      28134444
      10.1111/nyas.13300

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