Wireless smart contact lens for diabetic diagnosis and therapy

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Abstract

We demonstrate smart contact lenses for noninvasive and continuous diabetic diagnosis and diabetic retinopathy therapy.

Abstract

A smart contact lens can be used as an excellent interface between the human body and an electronic device for wearable healthcare applications. Despite wide investigations of smart contact lenses for diagnostic applications, there has been no report on electrically controlled drug delivery in combination with real-time biometric analysis. Here, we developed smart contact lenses for both continuous glucose monitoring and treatment of diabetic retinopathy. The smart contact lens device, built on a biocompatible polymer, contains ultrathin, flexible electrical circuits and a microcontroller chip for real-time electrochemical biosensing, on-demand controlled drug delivery, wireless power management, and data communication. In diabetic rabbit models, we could measure tear glucose levels to be validated by the conventional invasive blood glucose tests and trigger drugs to be released from reservoirs for treating diabetic retinopathy. Together, we successfully demonstrated the feasibility of smart contact lenses for noninvasive and continuous diabetic diagnosis and diabetic retinopathy therapy.

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The rise of plastic bioelectronics.

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Plastic bioelectronics is a research field that takes advantage of the inherent properties of polymers and soft organic electronics for applications at the interface of biology and electronics. The resulting electronic materials and devices are soft, stretchable and mechanically conformable, which are important qualities for interacting with biological systems in both wearable and implantable devices. Work is currently aimed at improving these devices with a view to making the electronic-biological interface as seamless as possible.

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Wearable systems that monitor muscle activity, store data and deliver feedback therapy are the next frontier in personalized medicine and healthcare. However, technical challenges, such as the fabrication of high-performance, energy-efficient sensors and memory modules that are in intimate mechanical contact with soft tissues, in conjunction with controlled delivery of therapeutic agents, limit the wide-scale adoption of such systems. Here, we describe materials, mechanics and designs for multifunctional, wearable-on-the-skin systems that address these challenges via monolithic integration of nanomembranes fabricated with a top-down approach, nanoparticles assembled by bottom-up methods, and stretchable electronics on a tissue-like polymeric substrate. Representative examples of such systems include physiological sensors, non-volatile memory and drug-release actuators. Quantitative analyses of the electronics, mechanics, heat-transfer and drug-diffusion characteristics validate the operation of individual components, thereby enabling system-level multifunctionalities.

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Author and article information

Journal

Journal ID (nlm-ta): Sci Adv

Journal ID (iso-abbrev): Sci Adv

Journal ID (publisher-id): SciAdv

Journal ID (hwp): advances

Title: Science Advances

Publisher: American Association for the Advancement of Science

ISSN (Electronic): 2375-2548

Publication date Collection: April 2020

Publication date (Electronic): 24 April 2020

Volume: 6

Issue: 17

Electronic Location Identifier: eaba3252

Affiliations

[1 ]Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Korea.

[2 ]Department of Electrical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Korea.

[3 ]Department of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, Seoul 06591, Korea.

[4 ]Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Korea.

[5 ]Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, 65 Landsdowne St., UP-5, Cambridge, MA 02139, USA.

[6 ]PHI BIOMED Co., #613, 12 Gangnam-daero 65-gil, Seocho-gu, Seoul 06612, Korea.

[7 ]Department of Chemical Engineering, Stanford University, 443 Via Ortega, Stanford, CA 94305, USA.

[8 ]Byers Eye Institute at Stanford University School of Medicine, Palo Alto, CA 94304, USA.

Author notes

[*]

These authors contributed equally to this work.

[† ]Corresponding author. Email: skhanb@ 123456postech.ac.kr

Author information

Do Hee Keum http://orcid.org/0000-0003-3262-3168

Su-Kyoung Kim http://orcid.org/0000-0002-6017-2002

Jahyun Koo http://orcid.org/0000-0002-2951-9522

Geon-Hui Lee http://orcid.org/0000-0002-5181-873X

Cheonhoo Jeon http://orcid.org/0000-0002-4747-978X

Ehsan Kamrani http://orcid.org/0000-0002-0919-1179

Sangbaie Shin http://orcid.org/0000-0001-9119-9374

Jae-Yoon Sim http://orcid.org/0000-0003-1814-6211

Zhenan Bao http://orcid.org/0000-0002-0972-1715

Sei Kwang Hahn http://orcid.org/0000-0002-7718-6259

Article

Publisher ID: aba3252

DOI: 10.1126/sciadv.aba3252

PMC ID: 7182412

PubMed ID: 32426469

SO-VID: e8e835e2-c1bc-4938-ba56-49292cae3ec7

Copyright © Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

History

Date received : 23 November 2019

Date accepted : 31 January 2020

Funding

Funded by: the National Research Foundation (NRF);

Award ID: 2017R1E1A1A03070458

Funded by: the National Research Foundation (NRF);

Award ID: CASE-2015M3A6A5072945

Funded by: Samsung Science & Technology Foundation;

Award ID: SRFC-IT1401-03

Funded by: the Small and Medium Business Administration (SMBA);

Award ID: S2482887

Funded by: the National Eye Institute;

Award ID: K08EY028176

Funded by: the National Eye Institute;

Award ID: P30-EY026877

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Copyeditor Penchie Limbo

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Wireless smart contact lens for diabetic diagnosis and therapy

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Wearable biosensors for healthcare monitoring

The rise of plastic bioelectronics.

Multifunctional wearable devices for diagnosis and therapy of movement disorders.

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