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      Hormonal Treatments for Major Depressive Disorder: State of the Art

      1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , APA Council of Research Task Force on Novel Biomarkers and Treatments
      American Journal of Psychiatry
      American Psychiatric Association Publishing

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          Sex differences in anxiety and depression clinical perspectives.

          Sex differences are prominent in mood and anxiety disorders and may provide a window into mechanisms of onset and maintenance of affective disturbances in both men and women. With the plethora of sex differences in brain structure, function, and stress responsivity, as well as differences in exposure to reproductive hormones, social expectations and experiences, the challenge is to understand which sex differences are relevant to affective illness. This review will focus on clinical aspects of sex differences in affective disorders including the emergence of sex differences across developmental stages and the impact of reproductive events. Biological, cultural, and experiential factors that may underlie sex differences in the phenomenology of mood and anxiety disorders are discussed.
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            Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research.

            To summarize quantitatively the literature comparing hypothalamic-pituitary-adrenal (HPA) axis function between depressed and nondepressed individuals and to describe the important sources of variability in this literature. These sources include methodological differences between studies, as well as demographic or clinical differences between depressed samples.
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              Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin

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                Author and article information

                Journal
                American Journal of Psychiatry
                AJP
                American Psychiatric Association Publishing
                0002-953X
                1535-7228
                August 01 2020
                August 01 2020
                : 177
                : 8
                : 686-705
                Affiliations
                [1 ]Child Study Center and Department of Radiology and Biomedical Imaging, Yale University, New Haven, Conn. (Dwyer); Department of Psychiatry, Case Western Reserve University, Cleveland, and Northcoast Behavioral Healthcare Hospital, Northfield, Ohio (Aftab); Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis (Widge); Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, Calif., and VA Palo Alto Health Care System, Palo Alto, Calif. (Rodriguez);...
                Article
                10.1176/appi.ajp.2020.19080848
                32456504
                e8fd2b1c-e132-455f-9d9d-c0c00bf87d70
                © 2020
                History

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