Electron-Dense Deposits in Extraglomerular Vascular Structures in IgA Nephropathy

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Abstract

24 renal biopsies from 23 patients with IgA nephropathy (Berger’s disease) were examined. This retrospective ultrastructural study focused on extraglomerular vascular structures since information about these structures in IgA nephropathy is lacking. Electron-dense deposits were observed in arterioles in 8 out of 18 biopsies (44%), in which arterioles were available for electron microscopic examination. Deposits were absent in peritubular capillaries and in all arteries. The presence of deposits had no correlation with the patient’s blood pressure. The electron-dense deposits represent additional evidence that IgA nephropathy is a monosymptomatic form of a systemic disease that is mediated by circulating immune complexes of heterogenous origin.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1985

Publication date (Print): 1985

Publication date (Electronic): 04 December 2008

Volume: 39

Issue: 3

Pages: 179-183

Affiliations

Department of Pathology, University of Louisville School of Medicine, Louisville, Ky., USA

Article

Publisher ID: 183368 Other ID: Nephron 1985;39:179–183

DOI: 10.1159/000183368

PubMed ID: 3883208

SO-VID: e9009dcf-0297-414a-ac7a-d0d989175551

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 06 March 1984

Page count

Pages: 5

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