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      Electron-Dense Deposits in Extraglomerular Vascular Structures in IgA Nephropathy

      ,

      Nephron

      S. Karger AG

      IgA nephropathy, Berger’s disease, Electron Microscopy, Arterioles, Electron-dense deposits

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          Abstract

          24 renal biopsies from 23 patients with IgA nephropathy (Berger’s disease) were examined. This retrospective ultrastructural study focused on extraglomerular vascular structures since information about these structures in IgA nephropathy is lacking. Electron-dense deposits were observed in arterioles in 8 out of 18 biopsies (44%), in which arterioles were available for electron microscopic examination. Deposits were absent in peritubular capillaries and in all arteries. The presence of deposits had no correlation with the patient’s blood pressure. The electron-dense deposits represent additional evidence that IgA nephropathy is a monosymptomatic form of a systemic disease that is mediated by circulating immune complexes of heterogenous origin.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1985
          1985
          04 December 2008
          : 39
          : 3
          : 179-183
          Affiliations
          Department of Pathology, University of Louisville School of Medicine, Louisville, Ky., USA
          Article
          183368 Nephron 1985;39:179–183
          10.1159/000183368
          3883208
          © 1985 S. Karger AG, Basel

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          Pages: 5
          Categories
          Original Paper

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