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Light-triggered hydrophilic drug release from liposomes through removal of a photolabile protecting group†
research-article
21 December 2018
19 December 2018
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Abstract
The antibiotic penicillin G cannot be completely incorporated into hydrophobic lipid-membranes owing to its hydrophilicity. Through modification with a hydrophobic and photolabile protecting group, penicillin G was effectively incorporated into liposomes and released by photoirradiation at 365 nm.
Abstract
Penicillin G as an antibiotic was released from liposomes by increase of hydrophilicity by photocleavage of a hydrophobic protecting group.
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Most cited references2
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Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; aprroved standard - ninth edition. CLSI document M07-A9
CLSI (2012)
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The values of log Pow can be calculated using several software packages. The value for NNM-1 was calculated using Advanced Chemistry Development Software V11.02
(2024)