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Mechanisms of mitophagy in cellular homeostasis, physiology and pathology
August 28 2018
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Abstract
Mitophagy is an evolutionarily conserved cellular process to remove dysfunctional
or superfluous mitochondria, thus fine-tuning mitochondrial number and preserving
energy metabolism. In this Review, we survey recent advances towards elucidating the
molecular mechanisms that mediate mitochondrial elimination and the signalling pathways
that govern mitophagy. We consider the contributions of mitophagy in physiological
and pathological contexts and discuss emerging findings, highlighting the potential
value of mitophagy modulation in therapeutic intervention.