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      Determinación de insulina en bolsas multicapa de nutrición parenteral Translated title: Measurement of insulin in multilayer bags for parenteral nutrition

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          Abstract

          Resumen Introducción: es habitual adicionar insulina de acción rápida a las bolsas de nutrición parenteral (NP) para el manejo de la hiperglucemia. Sin embargo, la insulina puede adsorberse en las bolsas de NP debido a interacciones electroestáticas. Objetivo: determinar la estabilidad a 5 días y la influencia de la presencia de lípidos y de la concentración de insulina en las NP sobre la adsorción de insulina en las bolsas de NP. Método: se elaboraron 7 NP con el mismo volumen y con una composición semejante exceptuando la presencia de lípidos, los micronutrientes y la concentración de insulina. Se determinó la insulina mediante un inmunoensayo inmunométrico de electroquimioluminiscencia (ECLIA). Se tomaron muestras de 2 mL tras su preparación y en el día 5. Resultados: en el día 1, la pérdida media de insulina fue del 15,26 % (± 7,08) en las bolsas con lípidos y del 18,45 % (± 5,67) (p = 0,60) en las bolsas sin lípidos. El porcentaje de insulina perdido el día 5 en las NP con lípidos fue del 30,13 % (± 4,14) y en las NP sin lípidos del 44,71 % (± 12,94) (p = 0,052). No se observó correlación entre la cantidad de insulina adicionada a las bolsas de NP y el porcentaje perdido de insulina entre el día 1 (ρ = -0,407, p = 0,365), ni el día 5 (ρ = -0,295, p = 0,521). Conclusiones: hay un aumento de la adsorción de insulina en las bolsas de NP de etilenvinilacetato (EVA) con el paso del tiempo. La presencia de lípidos en las bolsas disminuye la adsorción. Son necesarios más estudios para demostrar cuáles son los factores asociados a la adsorción de insulina en las bolsas de EVA.

          Translated abstract

          Abstract Introduction: it is common to add rapid-acting insulin to parenteral nutrition (NP) bags for the management of hyperglycemia. However, insulin can be adsorbed in NP bags due to electrostatic interactions. Objective: to determine the influence of the presence of lipids and of insulin concentration in NP bags on the adsorption of insulin in these bags, as well as its stability for 5 days. Method: seven NP bags were prepared with the same volume and with a similar composition except for the presence of lipids and micronutrients, and insulin concentration. Insulin was determined by electrochemiluminescent immunoassay. Samples of 2 mL were taken after preparation and on day 5. Results: on day 1, the mean loss of insulin was 15.26 % (± 7.08) in the bags with lipids and 18.45 % (± 5.67) (p = 0.60) in the bags without lipids. The percentage of insulin lost by day 5 in the PN bags with lipids was 30.13 % (± 4.14), and in the PN bags without lipids it was 44.71 % (± 12.94) (p = 0,052). No correlation was observed between the amount of insulin added to the PN bags and the percentage of insulin lost between day 1 (ρ = -0.407, p = 0.365) or day 5 (ρ = -0.295, p = 0.521). Conclusions: there is an increase in insulin adsorption in NP EVA bags over time. The presence of lipids in the bags decreases adsorption. Further studies are needed to demonstrate the factors associated with insulin adsorption in EVA bags.

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          Effectiveness of regular versus glargine insulin in stable critical care patients receiving parenteral nutrition: a randomized controlled trial.

          To compare the effectiveness and safety of two glycemic control regimens in stable critical care patients receiving parenteral nutrition (PN).
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            Addition of Insulin to Parenteral Nutrition for Control of Hyperglycemia

            Administration of parenteral nutrition (PN) may result in hyperglycemia in patients with preexisting diabetes or disease-related insulin resistance, and it can be associated with increased rates of complications. Treatment requires insulin therapy. Insulin can be administered subcutaneously, intravenously via a variable rate sliding scale, or by adding it directly to the PN. The last method is a potentially attractive technique for a number of reasons-it could deliver the insulin intravenously at a steady rate alongside carbohydrates, and in malnourished patients with little subcutaneous tissue, it may prevent the need for frequent insulin injections. Despite such potential advantages, the addition of insulin to PN remains controversial, largely with respect to the bioavailability of insulin in PN and resultant concerns of the risk of hypoglycemia. There is a paucity of long-term quality controlled studies to address this question. The available literature suggests that, at least in the short term, insulin addition to PN can achieve reasonable glycemic control with low rates of hypoglycemia, and the technique compares favorably with the use of long-acting insulin preparations. This literature review finds a wide range of values reported for insulin availability via PN, ranging from 44% to 95% depending on the type of PN container material used and the presence of added vitamins and trace elements. Few studies looking at glycemic control among patients receiving home PN were found, and larger prospective trials are needed to assess the efficacy and safety of this technique in this patient group.
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              Insulin adsorption by glass infusion bottles, polyvinylchloride infusion containers, and intravenous tubing.

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                Author and article information

                Journal
                nh
                Nutrición Hospitalaria
                Nutr. Hosp.
                Grupo Arán (Madrid, Madrid, Spain )
                0212-1611
                1699-5198
                August 2021
                : 38
                : 4
                : 685-689
                Affiliations
                [1] Madrid orgnameHospital Universitario 12 de Octubre orgdiv1Servicio de Farmacia Spain
                [2] Madrid orgnameHospital Universitario 12 de Octubre orgdiv1Servicio de Bioquímica Spain
                Article
                S0212-16112021000400685 S0212-1611(21)03800400685
                10.20960/nh.03460
                e917b6e7-f5a4-409c-b11d-fe5566741929

                This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

                History
                : 01 December 2020
                : 15 January 2021
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 20, Pages: 5
                Product

                SciELO Spain

                Categories
                Trabajos Originales

                Insulin adsorption,Insulina regular,Nutrición parenteral,Adsorción de insulina,Regular insulin,Parenteral nutrition

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