7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The purpose of this paper is to examine the physical stability as well as viscoelastic properties of the binary amorphous ezetimibe–simvastatin system. According to our knowledge, this is the first time that such an amorphous composition is prepared and investigated. The tendency toward re-crystallization of the amorphous ezetimibe–simvastatin system, at both standard storage and elevated temperature conditions, have been studied by means of X-ray diffraction (XRD). Our investigations have revealed that simvastatin remarkably improves the physical stability of ezetimibe, despite the fact that it works as a plasticizer. Pure amorphous ezetimibe, when stored at room temperature, begins to re-crystallize after 14 days after amorphization. On the other hand, the ezetimibe-simvastatin binary mixture (at the same storage conditions) is physically stable for at least 1 year. However, the devitrification of the binary amorphous composition was observed at elevated temperature conditions ( T = 373 K). Therefore, we used a third compound to hinder the re-crystallization. Finally, both the physical stability as well as viscoelastic properties of the ternary systems containing different concentrations of the latter component have been thoroughly investigated.

          Related collections

          Most cited references49

          • Record: found
          • Abstract: not found
          • Article: not found

          ANALYSIS OF RECENT MEASUREMENTS OF THE VISCOSITY OF GLASSES

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Die Abhängigkeit der Viscosität von der Temperatur bie unterkühlten Flüssigkeiten

              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Insoluble drug delivery strategies: review of recent advances and business prospects

              The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility. Majority of the failures in new drug development have been attributed to poor water solubility of the drug. Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal drug delivery. About 40% of drugs with market approval and nearly 90% of molecules in the discovery pipeline are poorly water-soluble. With the advent of various insoluble drug delivery technologies, the challenge to formulate poorly water soluble drugs could be achieved. Numerous drugs associated with poor solubility and low bioavailabilities have been formulated into successful drug products. Several marketed drugs were reformulated to improve efficacy, safety and patient compliance. In order to gain marketing exclusivity and patent protection for such products, revitalization of poorly soluble drugs using insoluble drug delivery technologies have been successfully adopted by many pharmaceutical companies. This review covers the recent advances in the field of insoluble drug delivery and business prospects.
                Bookmark

                Author and article information

                Journal
                Pharmaceuticals (Basel)
                Pharmaceuticals (Basel)
                pharmaceuticals
                Pharmaceuticals
                MDPI
                1424-8247
                19 March 2019
                March 2019
                : 12
                : 1
                : 40
                Affiliations
                [1 ]Institute of Physics, University of Silesia, SMCEBI, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland; krzysztof.chmiel@ 123456smcebi.edu.pl (K.C.); karolina.jurkiewicz@ 123456us.edu.pl (K.J.); marian.paluch@ 123456us.edu.pl (M.P.)
                [2 ]Univ Lille, CNRS, UMR 8207, UMET, Unité Matériaux et Transformations, F59000 Villeneuve d’Ascq, France; natalia.correia@ 123456univ-lille.fr
                [3 ]Department of Physical Chemistry, Medical University of Gdansk, 84-416 Gdansk, Poland; wsawicki@ 123456gumed.edu.pl
                Author notes
                [* ]Correspondence: justyna.knapik-kowalczuk@ 123456us.edu.pl ; Tel.: +48-32-3497629
                Author information
                https://orcid.org/0000-0003-3736-8098
                https://orcid.org/0000-0003-4532-0051
                https://orcid.org/0000-0002-4289-7827
                Article
                pharmaceuticals-12-00040
                10.3390/ph12010040
                6469170
                30893881
                e93cb5d8-60d7-4c36-9b75-c8427944251e
                © 2019 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 05 March 2019
                : 16 March 2019
                Categories
                Article

                ezetimibe,simvastatin,co-amorphous,melt viscosity,solubility enhancement

                Comments

                Comment on this article