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      Kynurenate inhibition of cell excitation decreases stroke size and deficits.

      1 , , , ,

      Annals of neurology

      Wiley-Blackwell

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          Abstract

          Pharmacological inhibition of excitatory neurotransmission attenuates cell death in models of global ischemia/reperfusion and hypoglycemia. The current investigations extend these observations to a model of focal ischemia. Kynurenic acid, a broad-spectrum antagonist at excitatory amino acid receptors, was used as treatment (300 mg/kg; 3 doses at 4-hour intervals) before and after focal cerebral ischemia in rats (n = 54). Preischemia but not 1 hour postischemia treatment with kynurenate attenuated infarction size (p less than 0.001) and improved neurological outcome (p less than 0.001) studied at 24 hours after injury. These data support the role of excitatory neurotransmission in acute neuronal injury and support pharmacological inhibition of cell excitation as a potential therapy for stroke.

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          Author and article information

          Journal
          Ann. Neurol.
          Annals of neurology
          Wiley-Blackwell
          0364-5134
          0364-5134
          Dec 1987
          : 22
          : 6
          Affiliations
          [1 ] Department of Neurosurgery, University of California, San Francisco.
          Article
          10.1002/ana.410220609
          3435082

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