The emerging role of angiotensin-converting enzyme-2 in the kidney.

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Abstract

The intrarenal renin-angiotensin system contributes to the progression of chronic kidney disease. Angiotensin-converting enzyme-2 is a recently identified protein that is highly expressed in the kidney and results in formation of angiotensin-(1-7). This manuscript highlights current information on the localization and function of angiotensin-converting enzyme-2 in the kidney, along with recent studies on the role of the enzyme in hypertension, glomerulosclerosis, and diabetic nephropathy.

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Journal

Journal ID (iso-abbrev): Curr. Opin. Nephrol. Hypertens.

Title: Current opinion in nephrology and hypertension

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN: 1062-4821

ISSN (Print): 1062-4821

Publication date (Electronic): Mar 2007

Volume: 16

Issue: 2

Affiliations

[1 ] Kidney Research Centre, Division of Nephrology, The Ottawa Hospital, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada. kburns@ottawahospital.on.ca

Article

Publisher Item ID: 00041552-200703000-00010

DOI: 10.1097/MNH.0b013e3280123c0e

PubMed ID: 17293686

SO-VID: e950fa99-536e-4dcf-9936-61fadfaeebc5

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