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      Persistent High Prevalence of Thyroid Antibodies after Immunosuppressive Therapy in Subjects with Glomerulonephritis

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          The prevalence of thyroid antibodies, indicating an autoimmune thyroiditis, has been shown to be significantly increased in patients with autoimmune diseases. A 3-year prospective follow-up study of 42 patients with biopsy-confirmed glomerulonephritis is presented. Although the majority of patients had been treated with immunosuppressants, the prevalence of thyroid peroxidase antibodies was unchanged in both females and males, 47 and 15% respectively, at follow-up. Likewise, the prevalence of thyroglobulin antibodies was unaffected as was that of antinuclear antibodies (ANA) when analysing males and females together. However, for males there was a trend to higher prevalence for ANA at follow-up. On the other hand, the prevalence of antineutrophil cytoplasmic antibodies declined. Furthermore, thyroid antibodies were not restricted to membranous nephropathy, and notably found in 4 out of the 8 patients with vasculitis.

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          Prevention of relapses in Wegener's granulomatosis by treatment based on antineutrophil cytoplasmic antibody titre

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            The natural autoantibodies system: between hypotheses and facts.


              Author and article information

              Am J Nephrol
              American Journal of Nephrology
              S. Karger AG
              August 1998
              05 June 1998
              : 18
              : 4
              : 274-279
              Departments of a Nephrology in Lund, b Internal Medicine in Malmö and c Lund, Sweden; d Statens Seruminstitut, Copenhagen, Denmark; e Wieslab AB, Lund, Sweden
              13350 Am J Nephrol 1998;18:274–279
              © 1998 S. Karger AG, Basel

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              Page count
              Figures: 1, Tables: 2, References: 33, Pages: 6
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              Clinical Study


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