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      Relationship between urinary metals and lung function in college students

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          Abstract

          Objective To explore the association between urinary metals and lung function among college students, and to provide a theoretical basis for related research on metal exposure and lung function injury.

          Methods A total of 45 healthy college students were recruited from North China University of Science and Technology in Caofeidian between 2017—2018. During the four seasons, information was obtained from questionnaires and physical examinations, lung function parameters were assessed, including FVC, FEV1, PEF, FEV1/FVC and FEF 25–75, and morning urine samples were collected simultaneously. The urinary levels of 15 metals were measured by inductively coupled plasma mass spectrometry (ICP/MS); a Kruskal-Wallis H test was used to compare differences in urinary metals during the four seasons; and a mixed effect model was used to assess correlations between urinary metals and lung function.

          Results There were significant differences in the levels of urinary chromium, iron, nickel, copper, zinc, arsenic, selenium, selenium, molybdenum, cadmium, antimony and lead from 15 metals over the four seasons ( H=9.79–20.61, P<0.05). The differences observed in five lung function parameters over the four seasons were statistically significant ( F=61.72, 45.30, 47.61, 25.47, 35.13, P<0.05). The linear mixed effect model analysis showed that urinary concentrations of vanadium, manganese, iron, cobalt, nickel and antimony were negatively correlated with FEV1 ( B=0.202, 0.192, 0.181, 0.154, 0.131, 0.283); urinary concentrations of aluminum, vanadium, manganese, iron, cobalt, nickel, zinc, cadmium, and antimony were negatively correlated with FVC ( B=0.252, 0.290, 0.292, 0.271, 0.201, 0.180, 0.171, 0.163, 0.381); urinary concentrations of manganese and antimony were negatively correlated with PEF ( B=0.291, 0.354) ( P<0.05).

          Conclusion The increase of multiple metal concentrations among college students was related to lung function decline, the long-term metal exposure might lead to lung function damage. So environmental metal pollution should be controlled.

          Abstract

          【摘要】 目的 探讨大学生金属内暴露水平与肺功能的相关性, 为开展金属暴露与肺功能损伤的相关研究提供依据。 方法 以2017—2018年在华北理工大学曹妃甸校区招募的45名符合标准的大学生为研究对象, 分别于春、夏、秋、冬季进行 问卷随访调査和健康体检, 测量肺功能参数[用力肺活量(FVC)、1 s用力呼气容积(FEV1)、最大呼气流量(PEF)、FEV1/FVC和用力呼气流量(FEF 25~75)], 同时采集晨尿样本。尿液中15种金属含量使用电感耦合等离子体质谱法(ICP/MS)检 测;采用Kruskal-Wallis H检验比较不同季节尿液中金属含量的差异;运用线性混合效应模型分析尿液中金属组分暴露浓 度与肺功能之间的相关性。 结果 尿液15种金属元素中, 铬、铁、镍、铜、锌、砷、硒、钼、镉、锑、铅在4个季节的含量差异均 有统计学意义 ( H=9.79~20.61, P值均<0.05)。5项肺功能参数在4个季节的差异均有统计学意义( F值分别为61.72, 45.30, 47.61, 25.47, 35.13, P值均<0.05)。线性混合效应模型分析结果显示, 尿液中钒、锰、铁、钴、镍和锑含量与FEV1呈负 性相关( B值分别为0.202, 0.192, 0.181, 0.154, 0.131, 0.283); 尿液中铝、钒、锰、铁、钴、镍、锌、镉和锑的含量与FVC呈负性 相关( B值分别为0.252, 0.290, 0.292, 0.271, 0.201, 0.180, 0.171, 0.163, 0.381); 尿液中锰和锑的含量与PEF呈负相关( B值分别为0.291, 0.354) ( P值均<0.05)。 结论 大学生尿液中多种金属含量的增加与肺功能水平下降有关, 金属元素的长期 暴露有可能造成肺功能的损害, 应加强对环境金属污染的控制。

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          Author and article information

          Journal
          CJSH
          Chinese Journal of School Health
          Chinese Journal of School Health (China )
          1000-9817
          01 February 2022
          01 April 2022
          : 43
          : 2
          : 288-291
          Affiliations
          [1] 1Department of Clinical Medicine, Tangshan Vocational and Technical College, Tangshan (063000), Hebei Province, China
          Author notes
          *Corresponding author: WANG Qian, E-mail: wwqq517@ 123456aliyun.com
          Article
          j.cnki.1000-9817.2022.02.029
          10.16835/j.cnki.1000-9817.2022.02.029
          e96356f0-8127-4d60-901e-41fd52da23a7
          © 2022 Chinese Journal of School Health

          This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License (CC BY-NC 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc/4.0/.

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          Self URI (journal-page): http://www.cjsh.org.cn
          Categories
          Journal Article

          Ophthalmology & Optometry,Pediatrics,Nutrition & Dietetics,Clinical Psychology & Psychiatry,Public health
          Linear models,Students,Urine,Lung,Metals

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