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      Efficacy of Bromocriptine Administration for Selective Pituitary Resistance to Thyroid Hormone

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          Abstract

          The relation between thyroid-stimulating hormone (TSH) and triiodothyronine (T<sub>3</sub>) was evaluated in a girl with the selective pituitary type of thyroid hormone resistance for more than 7 years to clarify whether bromocriptine was an effective treatment or not. Levels of T3 (before: 2.44 ± 0.64 nmol/l, mean ± SD) and TSH (4.81 ± 2.52 mU/1) were significantly decreased during therapy (T<sub>3</sub>: 2.15 ± 0.44 nmol/l; TSH: 1.59 ± 0.78 mU/l). T<sub>3</sub> × TSH, calculated as one of the indices of pituitary resistance, on bromocriptine therapy (3.229 ± 1.255 mU/l × nmol/l) was significantly (p < 0.005) smaller than the product before the administration (11.298 ± 5.891 mU/l × nmol/l). The results suggest that bromocriptine should be one of the agents initially considered for the treatment of pituitary resistance to thyroid hormone.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1993
          1993
          03 December 2008
          : 39
          : 5-6
          : 229-234
          Affiliations
          aDepartment of Pediatrics, Faculty of Medicine, Tottori University, Yonago; bSecond Division, Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan
          Article
          182741 Horm Res 1993;39:229–234
          10.1159/000182741
          8314208
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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