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      The final steps of integrin activation: the end game.

      Nature reviews. Molecular cell biology

      Animals, Cytoplasm, metabolism, Humans, Integrins, Signal Transduction, Talin

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          Abstract

          Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby contributing to embryonic development and diseases such as atherothrombosis and cancer. Integrin activation comprises triggering events, intermediate signalling events and, finally, the interaction of integrins with cytoplasmic regulators, which changes an integrin's affinity for its ligands. The first two events involve diverse interacting signalling pathways, whereas the final steps are immediately proximal to integrins, thus enabling integrin-focused therapeutic strategies. Recent progress provides insight into the structure of integrin transmembrane domains, and reveals how the final steps of integrin activation are mediated by integrin-binding proteins such as talins and kindlins.

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          Author and article information

          Journal
          20308986
          3929966
          10.1038/nrm2871

          Chemistry

          Animals, Cytoplasm, metabolism, Humans, Integrins, Signal Transduction, Talin

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