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          Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine.

          The clinical performance of a laboratory test can be described in terms of diagnostic accuracy, or the ability to correctly classify subjects into clinically relevant subgroups. Diagnostic accuracy refers to the quality of the information provided by the classification device and should be distinguished from the usefulness, or actual practical value, of the information. Receiver-operating characteristic (ROC) plots provide a pure index of accuracy by demonstrating the limits of a test's ability to discriminate between alternative states of health over the complete spectrum of operating conditions. Furthermore, ROC plots occupy a central or unifying position in the process of assessing and using diagnostic tools. Once the plot is generated, a user can readily go on to many other activities such as performing quantitative ROC analysis and comparisons of tests, using likelihood ratio to revise the probability of disease in individual subjects, selecting decision thresholds, using logistic-regression analysis, using discriminant-function analysis, or incorporating the tool into a clinical strategy by using decision analysis.
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            Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

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              A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine.

              Based on statistical analysis of data in 186 children, a formula was derived which allows accurate estimation of glomerular filtration rate (GFR) from plasma creatinine and body lenght (GFR(ml/min/1.73 sq m) = 0.55 length (cm)/Per (mg/dl). Its application to clearance data in a separate group of 223 children reveals excellent agreement with GFR estimated by the Ccr (r = .935) or Cin (r = .905). This formula should be useful for adjusting dosages of drugs excreted by the kidney and detecting significant changes in renal function.
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                Author and article information

                Journal
                978-3-642-12921-6
                10.1007/978-3-642-12921-6
                Lexikon der Medizinischen Laboratoriumsdiagnostik
                Lexikon der Medizinischen Laboratoriumsdiagnostik
                978-3-642-12920-9
                978-3-642-12921-6
                21 December 2012
                : 1189-1275
                Affiliations
                [1 ]laboratoriumsmedizin köln, Dres. med. Wisplinghoff und Kollegen, Classen-Kappelmann-Straße 24, 50931 Köln,
                [2 ]Institut für Medizinische Diagnostik GmbH, Bioscientia, Konrad-Adenauer-Straße 17, 55218 Ingelheim,
                [3 ]GRID grid.411067.5, ISNI 0000000085849230, Institut für Laboratoriumsmedizin und Pathobiochemie, Molekulare Diagnostik Standort Marburg, , Universitätsklinikum Gießen und Marburg GmbH, ; Baldingerstraße, 35043 Marburg,
                [4 ]laboratoriumsmedizin köln, Dres. med. Wisplinghoff und Kollegen, Classen-Kappelmann-Straße 24, 50931 Köln,
                [5 ]Institut für Medizinische Diagnostik GmbH, Bioscientia, Konrad-Adenauer-Straße 17, 55218 Ingelheim,
                [6 ]GRID grid.411067.5, ISNI 0000000085849230, Institut für Laboratoriumsmedizin und Pathobiochemie, Molekulare Diagnostik Standort Marburg, , Universitätsklinikum Gießen und Marburg GmbH, ; Baldingerstraße, 35043 Marburg,
                Article
                19
                10.1007/978-3-642-12921-6_19
                7123623
                © Springer-Verlag Berlin Heidelberg 2013

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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                © Springer-Verlag Berlin Heidelberg 2013

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