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      Statin Use before By-Pass Surgery Decreases the Incidence and Shortens the Duration of Postoperative Atrial Fibrillation

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          Backround: The aim of the present observational study is to search the incidence of postoperative atrial fibrillation (AF) in patients with or without preoperative statin treatment. Methods and Results: The population consisted of 362 consecutive patients (267 on and 95 not on statin). Diabetes mellitus was more frequent in statin group (p = 0.03). Other demographic and procedural variables were similar in the both groups (All p > 0.05). Postoperative AF was less frequent and its duration was shorter in statin group compared to non-statin group (p = 0.03 and 0.0001, respectively). The Kaplan-Meier analysis showed the protective effect of statins against the risk of developing AF (p = 0.01). Conclusion: Statin treatment before the by-pass surgery decreases the incidence and shortens the duration of postoperative AF.

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          Most cited references 9

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          C-Reactive Protein Elevation in Patients With Atrial Arrhythmias

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            A perspective of postoperative atrial fibrillation in cardiac operations.

             Carla Cox (1993)
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              Usefulness of statin drugs in protecting against atrial fibrillation in patients with coronary artery disease.

              Atrial fibrillation (AF) is prevalent in the elderly, in patients with hypertension, and in patients with coronary artery disease (CAD). We hypothesized that statin therapy might be effective in preventing AF in patients with CAD and examined this hypothesis in a sample of patients with chronic stable CAD without AF, followed prospectively at a large outpatient cardiology practice. The association between statin use and the risk of developing AF was examined univariately and then with adjustment for potential confounding factors. Four hundred forty-nine men and women between the ages of 40 and 87 years were followed for an average of 5 years. Fifty-two patients (12%) developed AF during follow-up. Statin therapy was used by 59% of the patients during the study period and was associated with a significantly reduced risk of developing AF (crude odds ratio, 0.48, 95% confidence interval 0.28 to 0.83). This association remained significant after adjustment for potential confounders, including age, hypertension, left ventricular systolic function, occurrence of heart failure or acute ischemic events, and baseline cholesterol and changes in cholesterol levels (adjusted odds ratio 0.37, 95% confidence interval 0.18 to 0.76). Use of statins in patients with chronic stable CAD appears to be protective against AF. The underlying mechanism for this effect is unknown but appears to be independent of the reduction in serum cholesterol levels.

                Author and article information

                S. Karger AG
                February 2007
                18 July 2006
                : 107
                : 2
                : 117-121
                Departments of Cardiology and Cardiovascular Surgery, Suleyman Demirel University Medical School, Isparta, Turkey
                94589 Cardiology 2007;107:117–121
                © 2007 S. Karger AG, Basel

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                Page count
                Figures: 1, Tables: 3, References: 19, Pages: 5
                Original Research


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