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      NEONATAL SENSORINEURAL HEARING LOSS ASSOCIATED WITH FUROSEMIDE: A CASE-CONTROL STUDY

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      Developmental Medicine & Child Neurology

      Wiley

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          Most cited references 21

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          Cause of hearing loss in the high-risk premature infant

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            Furosemide ototoxicity: clinical and experimental aspects.

             S Rybak (1985)
            Furosemide is an ototoxic diuretic. Furosemide injection is followed by a rapid, but reversible decrease of the endocochlear potential and eighth nerve action potential with a more gradual decrease of the endolymph potassium concentration. In contrast to the reversible effects of furosemide alone on the cochlea, the combination of kanamycin with furosemide resulted in irreversible changes in cochlear function which were associated with elevated levels of kanamycin in the blood and perilymph of the experimental animals. There was a striking similarity between the blood level measured by high pressure liquid chromatography at the time of recovery of auditory function in experimental animals and the ototoxic blood levels proposed by others in clinical literature. These findings help to provide a pharmacologic basis for the clinical observation of furosemide-induced hearing loss.
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              Furosemide acutely decreases airways resistance in chronic bronchopulmonary dysplasia.

              We studied the effects of furosemide on pulmonary mechanics in 10 infants with bronchopulmonary dysplasia aged 41 +/- 1 (SE) weeks post-conception, gestational age at birth 30 +/- 1 wk, birth weight 1370 +/- 200 gm. Thoracic gas volume, airways resistance, and specific airway conductance were measured in an infant body pressure plethysmograph during quiet breathing. Dynamic pulmonary compliance was measured using an esophageal balloon. Infants with BPD had greater Raw, lower SGaw, and lower Cdyn than did 16 normal control infants. Within one hour after administration of furosemide 1 mg/kg IV to infants with BPD, Raw fell 36 +/- 13%, SGaw increased 84 +/- 22%, and Cdyn increased 54 +/- 13%; TGV did not change. Diuretic treatment of BPD in infants is associated with rapid, short-term improvement in Raw and Cdyn.
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                Author and article information

                Journal
                Developmental Medicine & Child Neurology
                Wiley
                00121622
                14698749
                September 1991
                November 12 2008
                : 33
                : 9
                : 816-823
                Article
                10.1111/j.1469-8749.1991.tb14966.x
                © 2008

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