The present study investigated the relationship between sense of coherence (SOC) and smoking. This study is a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial. SOC was assessed with a short form self-report questionnaire at baseline and at two-year follow-up. Smoking behaviour was self-reported at both dates. The sample consisted of 841 hypertensive participants, (women 22.1%) at baseline, and 697 (women 23.0%) participants at the follow-up. At baseline the age range was 40-79. Results showed that smoking behaviour was associated with levels of SOC. Current-smokers had a lower mean of SOC. Gender had no statistically significant influence on these results.