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      H 1- and H 2-Histamine Receptor Antagonists and Induced Release of Prolactin in Male Rats

      research-article
      Author(s): ,
      Publication date (Electronic):
      Journal: Neuroendocrinology
      Publisher: S. Karger AG
      Keywords: Prolactin release, Antihistamines, Histamine

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          Abstract

          The effects of 3rd ventricle injection of metiamide, an H<sub>2</sub>-histamine receptor antagonist and pyrilamine, an H<sub>1</sub>-histamine receptor antagonist, on the increase of plasma prolactin induced by two doses of histamine in normal male rats were studied. Metiamide did prevent the stimulating action of histamine whereas pyrilamine was not effective. Histamine-induced prolactin release was also blocked by low doses of the 2 antihistamines given in combination. Metiamide per se has no effect but high doses of pyrilamine increased plasma prolactin levels and augmented the hormone response to histamine. The results suggest mediation of H<sub>2</sub>-receptors in the facilitatory action of histamine on prolactin release.

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          Author and article information

          Journal
          Journal ID (publisher-id): NEN
          Journal ID (nlm-ta): Neuroendocrinology
          Journal ID (doi): 10.1159/issn.0028-3835
          Title: Neuroendocrinology
          Publisher: S. Karger AG
          ISSN (Print): 0028-3835
          ISSN (Electronic): 1423-0194
          Publication date Subscription-year: 1980
          Publication date (Print): 1980
          Publication date (Electronic): 26 March 2008
          Volume: 30
          Issue: 1
          Pages: 11-14
          Affiliations
          Instituto de Investigaciones Cerebrales, Facultad de Ciencias Médicas, Mendoza
          Article
          Publisher ID: 122967 Other ID: Neuroendocrinology 1980;30:11–14
          DOI: 10.1159/000122967
          PubMed ID: 7354886
          SO-VID: e99b6ad2-ac7c-4946-ad07-baf57ccc19d7
          Copyright © © 1980 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 05 March 1979
          Date accepted : 11 May 1979
          Page count
          Pages: 4
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Keywords: Prolactin release,Histamine,Antihistamines
          Data availability:
          ScienceOpen disciplines: Endocrinology & Diabetes, Neurology, Nutrition & Dietetics, Sexual medicine, Internal medicine, Pharmacology & Pharmaceutical medicine
          Keywords: Prolactin release, Histamine, Antihistamines

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