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      Stereologic estimation of hippocampal GluR2/3- and calretinin-immunoreactive hilar neurons (presumptive mossy cells) in two mouse models of temporal lobe epilepsy.

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          Abstract

          Hippocampal mossy cells receive dense innervation from dentate granule cells and, in turn, mossy cells innervate both granule cells and interneurons. Mossy cell loss is thought to trigger granule cell mossy fiber sprouting, which may affect granule cell excitability. The aim of this study was to quantify mossy cell loss in two animal models of temporal lobe epilepsy, and determine whether there exists a relationship between mossy cell loss, mossy fiber sprouting, and granule cell dispersion.

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          Author and article information

          Journal
          Epilepsia
          Epilepsia
          Wiley-Blackwell
          1528-1167
          0013-9580
          Sep 2011
          : 52
          : 9
          Affiliations
          [1 ] Department of Neurosurgery, University Medical Center, Albert-Ludwigs-University, Freiburg, Germany.
          Article
          10.1111/j.1528-1167.2011.03086.x
          21635231

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