Contributors
Marcel Hohl: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
VisualizationRole: Writing – original draftRole: Writing – review & editing
Aditya Mojumdar: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Visualization
Sarem Hailemariam: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Visualization
Vitaly Kuryavyi: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Visualization
Fiorella Ghisays: Role: Data curationRole: Formal analysisRole: InvestigationRole: Visualization
Kyle Sorenson: Role: Data curationRole: Formal analysisRole: Investigation
Matthew Chang: Role: MethodologyRole: Resources
Barry S. Taylor: Role: MethodologyRole: Resources
Dinshaw J. Patel: Role: ResourcesRole: Supervision
Peter M. Burgers: Role: Funding acquisitionRole: MethodologyRole: ResourcesRole: Supervision
Jennifer A. Cobb:
ORCID: http://orcid.org/0000-0002-2027-4098
Role: Funding acquisitionRole: MethodologyRole: ResourcesRole: Supervision
John H. J. Petrini:
ORCID: http://orcid.org/0000-0001-5102-5679
Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: SupervisionRole:
Writing – original draftRole: Writing – review & editing
Lorraine S. Symington: Role: Editor
Journal
Journal ID (nlm-ta): PLoS Genet
Journal ID (iso-abbrev): PLoS Genet
Journal ID (publisher-id): plos
Journal ID (pmc): plosgen
Title:
PLoS Genetics
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7390
ISSN
(Electronic):
1553-7404
Publication date
(Electronic):
18
March
2020
Publication date Collection:
March
2020
Volume: 16
Issue: 3
Electronic Location Identifier: e1008422
Affiliations
[1
]
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York,
United States of America
[2
]
Departments of Biochemistry & Molecular Biology and Oncology, Robson DNA Science Centre,
Arnie Charbonneau Cancer Institute, Cumming School of Medicine; University of Calgary,
Calgary, Canada
[3
]
Department of Biochemistry and Molecular Biophysics, Washington University School
of Medicine, St. Louis, Missouri, Untied States of America
[4
]
Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New
York, United States of America
[5
]
Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering
Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial
Sloan Kettering Cancer Center, New York, New York, United States of America
Columbia University, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PGENETICS-D-19-01515
DOI: 10.1371/journal.pgen.1008422
PMC ID: 7105138
PubMed ID: 32187176
SO-VID: e9ba9955-3af3-472d-9fc1-edaea520e446
Copyright © © 2020 Hohl et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 10
September
2019
Date
accepted
: 19
January
2020
Page count
Figures: 5,
Tables: 0,
Pages: 28
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100013401, Ovarian Cancer Research Fund Alliance;
Award ID: SU2C-AACR-DT16-15
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: GM56888
Award Recipient
:
ORCID: http://orcid.org/0000-0001-5102-5679
John H. J. Petrini
Funded by: funder-id http://dx.doi.org/10.13039/100007052, Memorial Sloan-Kettering Cancer Center;
Award ID: P30 CA008748
Award Recipient
:
ORCID: http://orcid.org/0000-0001-5102-5679
John H. J. Petrini
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: GM118129
Award Recipient
:
Peter M. Burgers
Funded by: funder-id http://dx.doi.org/10.13039/501100007202, CIHR Skin Research Training Centre;
Award ID: CIHR MOP-82736
Award Recipient
:
ORCID: http://orcid.org/0000-0002-2027-4098
Jennifer A. Cobb
Funded by: funder-id http://dx.doi.org/10.13039/501100004397, Ministry of Public Health;
Award ID: MOP-137062
Award Recipient
:
ORCID: http://orcid.org/0000-0002-2027-4098
Jennifer A. Cobb
Funded by: funder-id http://dx.doi.org/10.13039/501100002790, Canadian Network for Research and Innovation in Machining Technology, Natural Sciences
and Engineering Research Council of Canada;
Award ID: NSERC 418122
Award Recipient
:
ORCID: http://orcid.org/0000-0002-2027-4098
Jennifer A. Cobb
This work was supported by a Stand Up To Cancer-Ovarian Cancer Research Fund-Ovarian
Cancer National Alliance-National Ovarian Cancer Coalition Dream Team Translational
Cancer Research Grant (SU2C-AACR-DT16-15), GM56888, P01 CA087497 and MSK Cancer Center
Core Grant P30 CA008748 (J.H.J.P.), the Maloris Foundation (D.J.P.), Anna Fuller Fund
and the Josie Robertson Foundation (B.S.T), GM118129 (P.M.B.) and CIHR MOP-82736;
MOP-137062 and NSERC 418122 (J.A.C.). The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Saccharomyces Cerevisiae
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Saccharomyces Cerevisiae
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Fungi
Subject:
Yeast
Subject:
Saccharomyces
Subject:
Saccharomyces Cerevisiae
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Yeast and Fungal Models
Subject:
Saccharomyces Cerevisiae
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
DNA-binding proteins
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Computational Chemistry
Subject:
Molecular Dynamics
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Mutation
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
DNA
Subject:
DNA repair
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
DNA
Subject:
DNA repair
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Yeast and Fungal Models
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzymes
Subject:
Phosphatases
Subject:
Adenosine Triphosphatase
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Enzymes
Subject:
Phosphatases
Subject:
Adenosine Triphosphatase
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Reactions
Subject:
Hydrolysis
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