Simeprevir in combination with sofosbuvir in treatment-naïve and -experienced patients with hepatitis C virus genotype 4 infection: a Phase III, open-label, single-arm study (PLUTO).

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Abstract

Hepatitis C virus (HCV) infection is a leading cause of liver cirrhosis and subsequent hepatocellular carcinoma. HCV genotype 4 is found widely in the Middle East, Egypt and Africa, and has also spread into Europe. There are limited data available regarding the use of direct-acting antiviral agents in HCV genotype 4-infected patients with cirrhosis.

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Author and article information

Journal

Journal ID (iso-abbrev): Aliment. Pharmacol. Ther.

Title: Alimentary pharmacology & therapeutics

Publisher: Wiley-Blackwell

ISSN (Electronic): 1365-2036

ISSN (Print): 0269-2813

Publication date (Electronic): February 2017

Volume: 45

Issue: 3

Affiliations

[1 ] Hospital Vall d'Hebron and Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

[2 ] University Hospital Puerta de Hierro Majadahonda, Madrid, Spain.

[3 ] Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

[4 ] Quirón Valencia Hospital, Valencia, Spain.

[5 ] Consorcio Hospital General Universitario de Valencia, Valencia, Spain.

[6 ] Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain.

[7 ] Hospital Universitari Germans Trias i Pujol (CIBERehd), Barcelona, Spain.

[8 ] Valme University Hospital University of Seville, Sevilla, Spain.

[9 ] Hospital Ramón y Cajal, Madrid, Spain.

[10 ] Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), University Hospital Virgen del Rocío, Sevilla, Spain.

[11 ] Janssen Pharmaceutica NV, Beerse, Belgium.

[12 ] Janssen Research & Development, LLC, Titusville, NJ, USA.

Article

DOI: 10.1111/apt.13883

PubMed ID: 27896822

SO-VID: e9bd4cfb-1702-4aa5-8453-b4b5178514f8

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