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      Inhibitory Action of Urate on p-Aminohippurate Secretion by the Isolated Rat Kidney

      , ,

      Nephron

      S. Karger AG

      Urate, Uric acid, <italic>p</italic>-Aminohippurate, Isolated rat kidney

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          Abstract

          We utilized an isolated perfusion rat kidney preparation to assess the influence of uric acid on p-amino-hippurate (PAH) secretion. In the absence of urate, PAHsecretion averaged 183 µg/min (0.94 µmol/min) at a perfusate PAHconcentration of 3.2 mg/dl (0.16 mmol/l), and was not influenced by increasing the perfusate PAHto 45 mg/dl (2.3 mmol/l). After addition of urate to the perfusate, PAHsecretion was 73% less at a perfusate PAHof 2.4 mg/dl (0.12 mmol/l), and changed very little following a 20-fold increase in perfusate PAH. The results raise the possibility that urate may depress renal organic anion secretion in vivo.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 31
          : 3
          : 266-269
          Affiliations
          Department of Medicine, University of Wisconsin, Madison, Wisc., USA
          Article
          182657 Nephron 1982;31:266–269
          10.1159/000182657
          7121672
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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