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      The collagen family.

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      Cold Spring Harbor perspectives in biology

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          Abstract

          Collagens are the most abundant proteins in mammals. The collagen family comprises 28 members that contain at least one triple-helical domain. Collagens are deposited in the extracellular matrix where most of them form supramolecular assemblies. Four collagens are type II membrane proteins that also exist in a soluble form released from the cell surface by shedding. Collagens play structural roles and contribute to mechanical properties, organization, and shape of tissues. They interact with cells via several receptor families and regulate their proliferation, migration, and differentiation. Some collagens have a restricted tissue distribution and hence specific biological functions.

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          Author and article information

          Journal
          Cold Spring Harb Perspect Biol
          Cold Spring Harbor perspectives in biology
          1943-0264
          1943-0264
          Jan 2011
          : 3
          : 1
          Affiliations
          [1 ] Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS, Université Lyon 1, Lyon, 69367, France. s.ricard-blum@ibcp.fr
          Article
          cshperspect.a004978
          10.1101/cshperspect.a004978
          3003457
          21421911
          e9c08f2b-a1c9-4a37-bc2f-43c156ad9c19
          History

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