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The phosphoinositide 3-kinase pathway.

Science (New York, N.Y.)

Signal Transduction, Proto-Oncogene Proteins c-akt, metabolism, Proto-Oncogene Proteins, Protein-Serine-Threonine Kinases, Protein Kinases, Phosphorylation, chemistry, Phosphatidylinositol Phosphates, Phosphatidylinositol 4,5-Diphosphate, Phosphatidylinositol 3-Kinases, drug therapy, Neoplasms, Models, Biological, Humans, Diabetes Mellitus, Type 2, Cell Physiological Phenomena, Cell Membrane, Animals, 3-Phosphoinositide-Dependent Protein Kinases

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      Abstract

      Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.

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      Journal
      10.1126/science.296.5573.1655
      12040186

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