- Record: found
- Abstract: not found
- Article: not found
The Phosphoinositide 3-Kinase Pathway
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Phosphorylated lipids are produced at cellular membranes during signaling events and
contribute to the recruitment and activation of various signaling components. The
role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate,
in cell survival pathways; the regulation of gene expression and cell metabolism;
and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in
human diseases including diabetes and cancer, and understanding the intricacies of
this pathway may provide new avenues for therapuetic intervention.