11β-hydroxysteroid dehydrogenase type 1 is expressed in human sebaceous glands and regulates glucocorticoid-induced lipid synthesis and toll-like receptor 2 expression in SZ95 sebocytes.

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Abstract

Glucocorticoids (GCs) affect the pathophysiology of sebaceous glands, causing development or exacerbation of acne. The availability of GCs is regulated by isoenzymes of 11β-hydroxysteroid dehydrogenase (11βHSD) at tissue-specific levels. 11βHSD type 1 (HSD11β1) is a reductase, catalysing the conversion of cortisone to active cortisol, and is highly expressed in liver and adipose tissue. Recently, HSD11β1 was observed in human skin in keratinocytes and fibroblasts.

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Journal

Journal ID (iso-abbrev): Br. J. Dermatol.

Title: The British journal of dermatology

Publisher: Wiley

ISSN (Electronic): 1365-2133

ISSN (Print): 0007-0963

Publication date (Electronic): Jan 2013

Volume: 168

Issue: 1

Affiliations

[1 ] Department of Dermatology, CHA Bundang Medical Center, CHA University, 351, Yatap-dong, Bundang-gu, Seongnam 463-712, Korea.

Article

DOI: 10.1111/bjd.12009

PubMed ID: 22897663

SO-VID: e9c8da0b-c9ef-4217-980a-a5c97f8a7c95

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