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      Polysaccharide biomaterials for drug delivery and regenerative engineering : POLYSACCHARIDES AS BIOMATERIALS

      , , ,
      Polymers for Advanced Technologies
      Wiley-Blackwell

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          A review of chitin and chitosan applications

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            Biodegradable polymers as biomaterials

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              Biodegradation, biodistribution and toxicity of chitosan.

              Chitosan is a natural polysaccharide that has attracted significant scientific interest during the last two decades. It is a potentially biologically compatible material that is chemically versatile (-NH2 groups and various M(w)). These two basic properties have been used by drug delivery and tissue engineering scientists to create a plethora of formulations and scaffolds that show promise in healthcare. Despite the high number of published studies, chitosan is not approved by the FDA for any product in drug delivery, and as a consequence very few biotech companies are using this material. This review will aim to provide information on these biological properties that affect chitosan's safe use in drug delivery. The term "Chitosan" represents a large group of structurally different chemical entities that may show different biodistribution, biodegradation and toxicological profiles. Here we aim to review research in this area and critically discuss chitosan's potential to be used as a generally regarded as safe (GRAS) material. 2009 Elsevier B.V. All rights reserved.
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                Author and article information

                Journal
                Polymers for Advanced Technologies
                Polym. Adv. Technol.
                Wiley-Blackwell
                10427147
                May 2014
                May 05 2014
                : 25
                : 5
                : 448-460
                Article
                10.1002/pat.3266
                e9db0537-4d00-40eb-9843-66a3b9b5aa1b
                © 2014

                http://doi.wiley.com/10.1002/tdm_license_1.1

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                Self URI (article page): http://doi.wiley.com/10.1002/pat.3266

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