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      Postinfarction Exercise Capacity after Lidoflazine Treatment or Physical Training

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          44 male postinfarction volunteers were divided into 4 groups and submitted to performance tests. Groups I and II consisted of 24 patients, 12 of whom followed a 2-month physical training program, while the other 12 served as controls. Groups III and IV (10 patients each) were included in a 10-month double-blind crossover study with lidoflazine 240 mg/day vs. placebo. The cardiovascular adaptation of the patients treated for 5 months with lidoflazine had two features in common with that observed after 2 months of physical training, namely an increase in maximal exercise capacity and, during submaximal exercise tests, a decrease in heart rate compensated for by an increase in stroke volume. In contrast to physical training, treatment with lidoflazine did not improve the peripheral oxygen consumption by the muscles.

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          S. Karger AG
          31 October 2008
          : 64
          : 1
          : 35-47
          Laboratoire de Recherches cardiologiques; Clinique cardiologique; Département de Cardiologie, and Laboratoire de Physiologie cardio-pulmonaire of the Hôpital Universitaire Saint-Pierre, Brussels
          170576 Cardiology 1979;64:35–47
          © 1979 S. Karger AG, Basel

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          Pages: 13
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