Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial.

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Abstract

Dupilumab has demonstrated efficacy in patients with asthma and atopic dermatitis, which are both type 2 helper T-cell-mediated diseases.

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Journal

Journal ID (iso-abbrev): JAMA

Title: JAMA

Publisher: American Medical Association (AMA)

ISSN (Electronic): 1538-3598

ISSN (Print): 0098-7484

Publication date (Electronic): Feb 02 2016

Volume: 315

Issue: 5

Affiliations

[1 ] Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium2Clintec, Karolinska Institute, Stockholm, Sweden.

[2 ] Research and Development, Sanofi, Chilly Mazarin, France.

[3 ] University of Chicago, Chicago, Illinois.

[4 ] Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

[5 ] University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

[6 ] Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium.

[7 ] Laboratory of Experimental Immunology, Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.

[8 ] Research and Development, Sanofi, Bridgewater, New Jersey.

[9 ] Regeneron Pharmaceuticals Inc, Tarrytown, New York.

[10 ] Immunology and Inflammation Development Franchise, Sanofi Research and Development, Cambridge, Massachusetts.

Article

Publisher Item ID: 2484681

DOI: 10.1001/jama.2015.19330

PubMed ID: 26836729

SO-VID: ea04fb3d-5f9e-4cc9-b2bf-9382fa99d3ae

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