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      Effectiveness of Hemodialysis with High-Flux Polysulfone Membrane in the Treatment of Life-Threatening Methanol Intoxication



      S. Karger AG

      High-flux membranes, Metabolic acidosis, Methanol intoxication, Anion gap, Ethanol, Hemodialysis, Osmolal gap

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          Methanol poisoning may result in metabolic acidosis, blindness and death. In this report, we describe a case of life-threatening methanol intoxication in a 44-year-old man who was treated successfully with supportive care, ethanol infusion, folic acid and early hemodialysis with a high-flux polysulfone dialyzer. We conclude that hemodialysis as implemented in this case is a safe and effective approach to the management of methanol poisoning.

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          Pseudo-Normal Osmolal and Anion Gaps following Simultaneous Ethanol and Methanol Ingestion

          Methanol, ethylene glycol, and isopropyl alcohol are associated with acute intoxication. The diagnosis is dependent upon high anion-gap metabolic acidosis, and an osmolal gap between the calculated and the measured osmolality. Normal anion gap has been reported in some cases of concomitant methanol and ethanol ingestion, where the high serum levels of ethanol inhibited the metabolism of methanol by alcohol dehydrogenase. The osmolal gap in these cases was higher than expected for methanol, and served as a constant marker for a metabolic derangement. Herewith, we present a patient who presented with normal osmolal and anion gaps 36 h after ethanol and methanol ingestion, yet progressively developing ocular toxicity. Normal anion and osmolal gaps should not rule out earlier methanol poisoning.

            Author and article information

            S. Karger AG
            February 2002
            30 January 2002
            : 90
            : 2
            : 216-218
            Service of Nephrology, Hospital Central de Asturias, Oviedo, Spain
            49046 Nephron 2002;90:216–218
            © 2002 S. Karger AG, Basel

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            Tables: 1, References: 8, Pages: 3
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