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      Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial.

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          Abstract

          Whether intravenous tissue plasminogen activator (alteplase) is effective beyond 3 h after onset of acute ischaemic stroke is unclear. We aimed to test whether alteplase given 3-6 h after stroke onset promotes reperfusion and attenuates infarct growth in patients who have a mismatch in perfusion-weighted MRI (PWI) and diffusion-weighted MRI (DWI).

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          Author and article information

          Journal
          Lancet Neurol
          The Lancet. Neurology
          Elsevier BV
          1474-4422
          1474-4422
          Apr 2008
          : 7
          : 4
          Affiliations
          [1 ] Department of Neurology, Royal Melbourne Hospital, University of Melbourne, Australia. stephen.davis@mh.org.au
          Article
          S1474-4422(08)70044-9
          10.1016/S1474-4422(08)70044-9
          18296121
          ea05b6c6-6f2e-4532-8c44-d5a2258579d9
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