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Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial.
Stephen M Davis
1 ,
Geoffrey A Donnan ,
Mark W Parsons ,
Christopher Levi ,
Kenneth S Butcher ,
Andre Peeters ,
P Alan Barber ,
Christopher Bladin ,
Deidre A De Silva ,
Graham Byrnes ,
Jonathan B Chalk ,
John N Fink ,
Thomas E Kimber ,
David Schultz ,
Peter J Hand ,
Judith Frayne ,
Graeme Hankey ,
Keith Muir ,
Richard Gerraty ,
Brian M Tress ,
Patricia M Desmond
Apr 2008
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Abstract
Whether intravenous tissue plasminogen activator (alteplase) is effective beyond 3 h after onset of acute ischaemic stroke is unclear. We aimed to test whether alteplase given 3-6 h after stroke onset promotes reperfusion and attenuates infarct growth in patients who have a mismatch in perfusion-weighted MRI (PWI) and diffusion-weighted MRI (DWI).