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      Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of Ebola virus hemorrhagic fever.

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          Abstract

          In humans and nonhuman primates, Ebola virus causes a virulent viral hemorrhagic fever for which no licensed vaccines or therapeutic drugs exist. In the present study, we used the mouse model for Ebola hemorrhagic fever to assess the safety and efficacy of a vaccine based on a live attenuated vesicular stomatitis virus expressing the Zaire ebolavirus (ZEBOV) glycoprotein.

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          Author and article information

          Journal
          J Infect Dis
          The Journal of infectious diseases
          University of Chicago Press
          0022-1899
          0022-1899
          Nov 15 2007
          : 196 Suppl 2
          Affiliations
          [1 ] Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Canada. Steven_jones@phac-aspc.gc.ca
          Article
          JID38161
          10.1086/520591
          17940977
          ea241ef0-5d75-4fce-8aca-fdec380aa997

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