Flaviviral RNA Structures and Their Role in Replication and Immunity.

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Abstract

More than simple vectors of genetic information, flaviviral RNAs have emerged as critical regulators of the virus life cycle. Viral RNAs regulate interactions with viral and cellular proteins in both, mosquito and mammalian hosts to ultimately influence processes as diverse as RNA replication, translation, packaging or pathogenicity. In this chapter, we will review the current knowledge of the role of sequence and structures in the flaviviral RNA in viral propagation and interaction with the host cell. We will also cover the increasing body of evidence linking viral non-coding RNAs with pathogenicity, host immunity and epidemic potential.

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Journal

Journal ID (iso-abbrev): Adv Exp Med Biol

Title: Advances in experimental medicine and biology

Publisher: Springer Science and Business Media LLC

ISSN: 0065-2598

ISSN (Print): 0065-2598

Publication date (Electronic): May 31 2018

Volume: 1062

Affiliations

[1 ] Infectious Diseases IRG, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.

[2 ] Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.

[3 ] Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.

Article

DOI: 10.1007/978-981-10-8727-1_4

PubMed ID: 29845524

SO-VID: ea397a4d-84a5-41a5-b0af-9e09b07a771f

History

Keywords: Structures,Flavivirus,RNA,Pathogenesis,Replication

Data availability:

Keywords: Structures, Flavivirus, RNA, Pathogenesis, Replication

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