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Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians.
S Lillioja
1 ,
D M Mott ,
M Spraul ,
R Ferraro ,
J E Foley ,
E Ravussin ,
W C Knowler ,
P H Bennett ,
C Bogardus
Dec 30 1993
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Abstract
The relative roles of obesity, insulin resistance, insulin secretory dysfunction, and excess hepatic glucose production in the development of non-insulin-dependent diabetes mellitus (NIDDM) are controversial. We conducted a prospective study to determine which of these factors predicted the development of the disease in a group of Pima Indians.