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      Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides

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          Abstract

          Quorum-sensing (QS) peptides are biologically attractive molecules, with a wide diversity of structures and prone to modifications altering or presenting new functionalities. Therefore, the Quorumpeps database ( http://quorumpeps.ugent.be) is developed to give a structured overview of the QS oligopeptides, describing their microbial origin (species), functionality (method, result and receptor), peptide links and chemical characteristics (3D-structure-derived physicochemical properties). The chemical diversity observed within this group of QS signalling molecules can be used to develop new synthetic bio-active compounds.

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          Most cited references53

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          A relational model of data for large shared data banks

          E F Codd (1970)
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            Structural identification of a bacterial quorum-sensing signal containing boron.

            Cell-cell communication in bacteria is accomplished through the exchange of extracellular signalling molecules called autoinducers. This process, termed quorum sensing, allows bacterial populations to coordinate gene expression. Community cooperation probably enhances the effectiveness of processes such as bioluminescence, virulence factor expression, antibiotic production and biofilm development. Unlike other autoinducers, which are specific to a particular species of bacteria, a recently discovered autoinducer (AI-2) is produced by a large number of bacterial species. AI-2 has been proposed to serve as a 'universal' signal for inter-species communication. The chemical identity of AI-2 has, however, proved elusive. Here we present the crystal structure of an AI-2 sensor protein, LuxP, in a complex with autoinducer. The bound ligand is a furanosyl borate diester that bears no resemblance to previously characterized autoinducers. Our findings suggest that addition of naturally occurring borate to an AI-2 precursor generates active AI-2. Furthermore, they indicate a potential biological role for boron, an element required by a number of organisms but for unknown reasons.
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              Bacterially speaking.

              Bacteria use a variety of means to communicate with one another and with their eukaryotic hosts. In some cases, social interactions allow bacteria to synchronize the behavior of all of the members of the group and thereby act like multicellular organisms. By contrast, some bacterial social engagements promote individuality among members within the group and thereby foster diversity. Here we explore the molecular mechanisms underpinning some recently discovered bacterial communication systems. These include long- and short-range chemical signaling channels; one-way, two-way, and multi-way communication; contact-mediated and contact-inhibited signaling; and the use and spread of misinformation or, more dramatically, even deadly information.
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                Author and article information

                Journal
                Nucleic Acids Res
                Nucleic Acids Res
                nar
                nar
                Nucleic Acids Research
                Oxford University Press
                0305-1048
                1362-4962
                January 2013
                January 2013
                23 November 2012
                23 November 2012
                : 41
                : D1 , Database issue
                : D655-D659
                Affiliations
                1Drug Quality and Registration (DruQuaR) group, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, 2Department of Telecommunications and Information Processing, Faculty of Engineering and Architecture and 3Department of Radiotherapy and Nuclear Medicine, Faculty of Medicine and Health Sciences, Ghent Hospital University, Ghent B-9000, Belgium
                Author notes
                *To whom correspondence should be addressed. Tel: +32 9 264 81 00; Fax: +32 9 264 81 93; Email: Bart.DeSpiegeleer@ 123456UGent.be
                Article
                gks1137
                10.1093/nar/gks1137
                3531179
                23180797
                ea4180c2-cf02-47fd-9017-b92bd158be3b
                © The Author(s) 2012. Published by Oxford University Press.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

                History
                : 26 June 2012
                : 16 October 2012
                : 24 October 2012
                Page count
                Pages: 5
                Categories
                Articles

                Genetics
                Genetics

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