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      Untersuchung der CO 2-abhängigen Gefäßregulation in der Netzhaut von Patienten mit Typ-1-Diabetes

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          Background: Diabetic retinopathy is characterised by morphological lesions in the retina secondary to disturbances in retinal blood flow. Previous studies have shown that the carbonic anhydrase inhibitor (CAI) dorzolamide can induce immediate dilatation of retinal arterioles and a sustained increase in retinal blood flow in primary open-angle glaucoma. However, the effect of sustained treatment with CAI on retinal arterioles in normal persons and in patients with diabetic retinopathy is unknown. Methods: The Dynamic Vessel Analyzer was used to assess the baseline diameter and the diameter response of retinal arterioles during an increase in arterial blood pressure induced by isometric exercise and during flicker stimulation before and 2 h, 24 h and 1 week after onset of topical treatment with dorzolamide. At each examination the diameter responses were studied before and during breathing in of a hypercapnic gas mixture. Results: Treatment with dorzolamide for 1 week significantly increased the diameter of retinal arterioles in normal persons, and breathing in of a hypercapnic gas mixture reduced this response. The pathological vasodilatation and reduced retinal autoregulation in patients with diabetic retinopathy were unaffected by dorzolamide and hypercapnia. Conclusions: The study suggests a lack of relevance of CAI for the treatment of pathological vasodilatation in early diabetic retinopathy.

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          Author and article information

          Karger Kompass Ophthalmologie
          S. Karger AG
          May 2020
          05 May 2020
          : 6
          : 2
          : 83-84
          Experimentelle Ophthalmologie, Klinik für Augenheilkunde, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Deutschland
          Author notes
          *Prof. Dr. Olaf Strauß, Experimentelle Ophthalmologie, Klinik für Augenheilkunde, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Deutschland, olaf.strauss@charite.de
          507718 Kompass Ophthalmol 2020;6:83-84
          © 2019 S. Karger GmbH, Freiburg

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          Page count
          References: 4, Pages: 2


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